Studies on Globefish Poison : (5) Urinary Excretion of the Poison and Effect of Various Diuretics on its Excretion and the Poisoned Animal

As was found in the previous paper, a considerable amount of intact globefish poison was excreted into urine, especially in the early stage of the poisoning in the rabbit injected with the toxin and a marked decrease of urine volume was simultaneously observed at early stages. Both facts suggested that if the urine volume is made augmented by the treatment of some diuretics, urinary excretion of the toxin would rapidly increase and accordingly a poisoned animal might survive longer or could be relieved of the death. A study was therefore attempted to examine the effect of various diuretics on the urine volume and urinary excretion of the toxin, and a comparison of time of death, mortality and the symptom was made between poisoned animals treated with diuretics and those untreated. The assay of the toxin excreted into urine was carried out biologically with mice as usual. ...