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publish year2020 - 2024 resource typejournal article
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Creators : Kawamura Daichi | Hirata Ken | Orita Masahiko Publishers : 山口大学医学会 Date Issued : 2021-12-02
We report the case of a 48-year-old woman with relapsed B-lineage acute lymphoblastic leukemia(B-ALL)following cord blood transplantation, in which leukemic cell CD22 antigens became negative after a single administration of inotuzumab ozogamicin(InO).At relapse, a major part of leukemic cells expressed CD19 and CD22 antigens, however some leukemic cells were negative for CD22. As treatment with blinatumomab proved ineffective, InO therapy was subsequently initiated
Creators : Sakai Kohei | Tominaga Takayuki | Nakano Kohei | Matsumura Takuro | Tanaka Shinsuke | Takahashi Toru Publishers : 山口大学医学会 Date Issued : 2021-12-02
Creators : Shirafuta Maya | Amiki Masae | Asaumi Natsuki | Kiriake Yuya | Ikuta Namika | Adachi Keiichiro | Tanaka Aiko Publishers : 山口大学医学会 Date Issued : 2021-12-02
Creators : Saeki Issei Publishers : 山口大学医学会 Date Issued : 2021-12-02
Creators : Honda Takeshi Publishers : 山口大学医学会 Date Issued : 2021-12-02
Creators : Ishikawa Yoshiko | Ito Misae Publishers : 山口大学医学会 Date Issued : 2021-09-01
Creators : Ikeda Yasuhiro | Muroya Satomi | Satou Kazutaka | Inoue Goichi | Koike Kunihiko | Maekawa Tsuyoshi Publishers : 山口大学医学会 Date Issued : 2021-09-01
Creators : Tanaka Aiko | Nagata Chizuru | Goth Miyuki Publishers : 山口大学医学会 Date Issued : 2021-09-01
We performed this study to investigate whether serum cell-free DNA testing(liquid biopsy)of either methylated SEPT9 or methylated SST, which are possible biomarkers of HCC, in combination with AFP may improve clinical performance for the detection of HCC. Study subjects included 25 healthy controls, 15 patients with chronic liver disease without HCC, and 38 patients with HCC. Methylation level of serum cell-free SEPT9 and SST was measured by methylation-sensitive restriction enzymes followed by multiplex droplet digital polymerase chain reaction. According to receiver operating characteristic curve analysis to discriminate between non-HCC group(including control group and chronic liver disease without HCC group)and HCC group, area under the curve(AUC)was 0.73 by AFP and 0.73 by mSEPT9, whereas it was only 0.59 by mSST. Regarding combination tests, although negative predictive values were almost same between the AFP + mSEPT9 test and the AFP + mSST test(75.0% vs 72.2%),a positive predictive value of AFP + mSEPT9 test was higher than that of the AFP + mSST test(79.4% vs. 66.7%).In conclusions, methylated SEPT9 was a better companion marker of AFP for HCC screening than methylated SST.
Creators : Yamasaki Ayano | Suehiro Yutaka | Hoshida Tomomi | Saeki Issei | Yamauchi Kotoh Yurika | Matsumoto Toshihiko | Takami Taro | Sakaida Isao | Yamasaki Takahiro Publishers : 山口大学医学会 Date Issued : 2021-09-01
Creators : 高田 雅也 | 神野 有生 | 加賀谷 仁秀 | 春名 正基 Date Issued : 2021-09-10
Creators : Fujimura Kazumi | Hase Ryosuke | Kijima Ayano | Okochi Ayako | Kumagai Tamaki Publishers : 山口大学医学会 Date Issued : 2021-05-13
Creators : Suetomi Takeshi Publishers : 山口大学医学会 Date Issued : 2021-05-13
Reports of 2019 fiscal year East Asian project studies
Journal of East Asian studies Volume 19
Publishers : 山口大学大学院東アジア研究科 Date Issued : 2021-03-01
Creators : Dutta Arijita | Asamizu Munehiko Publishers : 山口大学大学院東アジア研究科 Date Issued : 2021-03-01
Creators : Perlaky Denes Publishers : 山口大学大学院東アジア研究科 Date Issued : 2021-03-01
Creators : Jiang Yuxuan Publishers : 山口大学大学院東アジア研究科 Date Issued : 2021-03-01
Creators : Zhou Xiaofei Publishers : 山口大学大学院東アジア研究科 Date Issued : 2021-03-01
Creators : Wahyono Budi Publishers : 山口大学大学院東アジア研究科 Date Issued : 2021-03-01
Creators : Putu Ayu Asty Senja Pratiwi Publishers : 山口大学大学院東アジア研究科 Date Issued : 2021-03-01
Creators : Cheng Shuhuai Publishers : 山口大学大学院東アジア研究科 Date Issued : 2021-03-01