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Body composition as a novel prognostic biomarker for the patients with advanced hepatocellular carcinoma

山口医学 Volume 70 Issue 4

Creators : Saeki Issei Publishers : 山口大学医学会 Date Issued : 2021-12-02

Novel mechanisms regulating myogenic differentiation in skeletal muscle

山口医学 Volume 70 Issue 4

Creators : Honda Takeshi Publishers : 山口大学医学会 Date Issued : 2021-12-02

Liquid biopsy test based on a sensitive dna methylation assay for diagnosing hepatocellular carcinoma : which is a better marker, methylated sst or sept9?

山口医学 Volume 70 Issue 3

We performed this study to investigate whether serum cell-free DNA testing(liquid biopsy)of either methylated SEPT9 or methylated SST, which are possible biomarkers of HCC, in combination with AFP may improve clinical performance for the detection of HCC. Study subjects included 25 healthy controls, 15 patients with chronic liver disease without HCC, and 38 patients with HCC. Methylation level of serum cell-free SEPT9 and SST was measured by methylation-sensitive restriction enzymes followed by multiplex droplet digital polymerase chain reaction. According to receiver operating characteristic curve analysis to discriminate between non-HCC group(including control group and chronic liver disease without HCC group)and HCC group, area under the curve(AUC)was 0.73 by AFP and 0.73 by mSEPT9, whereas it was only 0.59 by mSST. Regarding combination tests, although negative predictive values were almost same between the AFP + mSEPT9 test and the AFP + mSST test(75.0% vs 72.2%),a positive predictive value of AFP + mSEPT9 test was higher than that of the AFP + mSST test(79.4% vs. 66.7%).In conclusions, methylated SEPT9 was a better companion marker of AFP for HCC screening than methylated SST.

Investigation of the factors of attendance and continuous to participate in dementia café among community-dwelling seniors

山口医学 Volume 70 Issue 2

Creators : Fujimura Kazumi | Hase Ryosuke | Kijima Ayano | Okochi Ayako | Kumagai Tamaki Publishers : 山口大学医学会 Date Issued : 2021-05-13

Sterile inflammation as a novel therapeutic target to heart failure

山口医学 Volume 70 Issue 2

Creators : Suetomi Takeshi Publishers : 山口大学医学会 Date Issued : 2021-05-13

Nobiletin, a citrus flavonoid, suppresses SPC-induced abnormal vascular contraction

山口医学 Volume 70 Issue 1

Creators : Miyanari Kenji Publishers : 山口大学医学会 Date Issued : 2021-03-04

A case of raspberry-like foveolar-type gastric adenocarcinoma resected by strip biopsy

山口医学 Volume 70 Issue 1

The different effects of acacetin and biochanin A on abnormal contraction of vascular smooth muscle