Pathological Studies on Trypanosomiasis 2.Histopathological Changes of Visceral Organs, Skin and Muscles of Surra Rabbits

This report deals with the histopathological studies of spleen, lympho nodes, heart, lungs, liver, ileum, kidneys, skin ani muscles in surra rabbits inoculated subcutaneously. The rabbits were infected with Trypanosoma evansi subcutaneously. Then the courses were relapsing type infection and the parasites were scanty in the blood circulation during the course of disease. As an addition to the literature of this disease the author described the pathological changes in the carcass of dead surra rabbits as follows : 1. He noted the thrombosis in the capillaries of alveolar septa of lungs and in vein sinuses of spleen, accompained the trypanosomac emboli in the both organs of the animal died. He did not note these pathological changes in the cases killed during the course of the disease. The changes may be inferred to be one of the mechanical causes for the lethal effect of surra trypanofomes infection of rabbits. 2. He noted the wide inflammatory, changes of the subderma of the dorsal region surrounding the inoculated site. These changes included hyperplasia of rmacrophages, perivascular infiltration of lymphocytes and trypanosomac debris. The parasites may have been placed in the subderma by the initial infection and may hane effected the pathological changes 3. He noted the swelling of the lumbar lymph nodes near the inoculated site. The lymph nodes showed the hemorrhages and necrosis of lymph follicles and the marked sinus catarral. The many macrophages appeared in the lymph canals of these lymph nodes. These changes suggested the trypanosomac tissue parasitism in the subderma of the site of inoulation. 4. He noted the degenerative changes and cell infiltration of muscle fibres in the muscle longissimus dorsi. These changes were thought to be one of the caues of the paresis and the apathetic condition of the disease. These parasites were suggested to indicate the slight degree of muscle tissue invasiveness in the rabbits.