Contents Menu
resource typejournal article
resource type
results 7503 items
Id (<span class="translation_missing" title="translation missing: en.view.desc">Desc</span>)
Anaplastic large cell lymphoma(ALCL)is a rare peripheral T-cell lymphoma. According to anaplastic lymphoma kinase(ALK)expression, the World Health Organization classifies ALCL into two subtypes:ALK-positive or ALK-negative. Anthracycline-based combination chemotherapy is a standard frontline treatment for ALK-positive ALCL, with a long-term event- free survival rate of 60%-70%. For the salvage treatments of relapsed or refractory cases, the efficacies of brentuximab vedotin or ALK inhibitor have been established. We undertook a phase II clinical trial to investigate the efficacy and safety of alectinib, which is a second-generation ALK inhibitor, for relapsed or refractory ALK-positive ALCL. Ten patients were enrolled, and objective responses were documented in eight patients(80%),with six complete responses. Allogeneic hematopoietic stem cell transplantation(allo-HSCT)has also been reported to be one of curative treatments for relapsed or refractory ALCL. However, a high rate of treatment-related mortality was observed in allo-HSCT because of the myeloabrative conditioning regimen. We have reported the efficacy of the reduced-intensity conditioning(RIC)regimen for relapsed or refractory ALCL including the patients who did not obtain complete remission at allo-HSCT. The RIC regimen might be able to improve the outcomes of allo-HSCT by reducing treatment-related mortality.
Creators : Fukano Reiji Publishers : Yamaguchi University medical association Date Issued : 2022-12-01
A 69-year-old deaf-mute man received 6 cycles of R-CHOP therapy for diffuse large B-cell lymphoma(DLBCL)of the stomach. Although he showed a complete response to this therapeutic regimen, the patient developed intractable diarrhea upon completion of chemotherapy. He was diagnosed with cytomegalovirus(CMV)enteritis and was administered ganciclovir and foscarnet;however, CMV infection persisted. We suspected immunodeficiency other than that associated with chemotherapy-induced immunosuppression. Further examinations revealed a decrease in the CD4^+ T lymphocyte count and positive results on anti-human immunodeficiency virus(HIV)antibody testing, which confirmed HIV infection, and he was diagnosed with acquired immunodeficiency syndrome(AIDS).Antiviral therapy was initiated, and the HIV-RNA viral load became undetectable;however, the CD4^+ T lymphocyte count recovery was insufficient. Despite the clinical presentation of an AIDS-indicator disease, diagnosis of HIV infection was delayed, which may be attributable to deaf-mutism and the patient’s advanced age that may have led to bias among the medical staff and prevented prompt diagnosis of HIV infection.
Creators : Hamada Risako | Sakai Kohei | Konaka Kiminori | Nakayama Ayana | Nakano Kohei | Matsumura Takuro | Tominaga Takayuki | Fujioka Yuka | Takahashi Toru Publishers : Yamaguchi University medical association Date Issued : 2022-08-31
Forensic pathologists perform autopsies and external examinations of deceased bodies to judge the cause of death. Forensic autopsies are only carried out in a small percentage of all deaths, and are performed for cases in which the cause of death is unknown and because many of these cases have background social problems. Therefore, both the cause and circumstances of death are important to those in related fields, and it is particularly significant to share information from forensic autopsies and to discuss prevention of recurrence in similar cases with persons involved in these fields. This report provides an overview of the forensic autopsies performed at our department in 2021. In the near future, we intend to share these cases through participation in workshops and conferences with related clinical departments, health and welfare workers, and medical scientists, so that this forensic autopsy information can be used effectively.
Creators : Himemiya-Hakucho Ayako | Nakagawa Aoi | Sakai Hiroki | Shigemoto Azumi | Takase Izumi Publishers : Yamaguchi University medical association Date Issued : 2022-08-31
The number of children requiring medical care is on the rise, reducing childcare burdens and establishing support systems' urgent undertakings. Public health nurses at public health centers are in a position to shoulder these responsibilities. This study aimed to clarify the activities performed by public health nurses at public health centers for children requiring medical care based on the content of support in individual cases. Interview surveys covering a summary of support and community resources were conducted for four individual cases. Analysis was performed using the practical competencies framework required of public health nurses at public health centers.As a result, 260 activities of public health nurses were organized into 79 codes and 39 categories and categorized according to the framework of practical competencies required of public health nurses at public health centers. Public health nurses at public health centers were found to provide direct support, categorized into“interpersonal support competency,”based on the prerequisite that patients require 24-hour medical care, and characterized by connecting medicine and welfare to manage the family unit. Public health nurses also provide indirect support, categorized into“community support competency,”“policy competency,”and“management competency,”in which they were understood to be attempting to build a care system through individual support.
Creators : Goto Naho | Ushio Yuko | Morita Takae Publishers : Yamaguchi University medical association Date Issued : 2022-08-31
This study aimed to evaluate the effects of care incorporating passive motion exercise of the ankle plantar dorsiflexion on lower extremity hemodynamics and comfort using physical methods for deep vein thrombosis(DVT)prevention. We recruited 16 healthy women, aged 20-40 years old, using a simple random allocation crossover design. We categorized them into three groups:intermittent pneumatic compression was performed continuously(IPC group);the patients underwent passive exercise of ankle dorsiflexion and plantar flexion(ankle exercise group),and IPC was removed(IPC removal group).We evaluated lower extremity hemodynamics, coagulation and fibrinolysis, autonomic nervous functions, and subjective sensation during each intervention.The ankle exercise group showed a decrease in the maximum blood flow velocity in the femoral vein and deoxygenated hemoglobin. Three coagulation and fibrinolysis complexes, namely, fibrin monomer complex, thrombin-antithrombin complex, and plasmin-alpha2-plasmininhibitor-complex, showed no change among the three groups. One autonomic nervous function, the high-frequency component, remained lower in the IPC group than in the other two groups after 15 minutes. Subjective sensation was highest in the IPC group.The ankle exercise group did not show exacerbation of lower limb venous stasis and coagulability, suggesting that a nursing intervention reduces discomfort that occurs with continuous use of IPC.
Creators : Shimaoka Maya | Yamase Hiroaki | Tado Asami | Mukae Gou Publishers : Yamaguchi University medical association Date Issued : 2022-08-31
Creators : Araki Hideki | Ueno Hirotaka | Mizuta Keisuke | Takahashi Tadashi | Shibata Masaru | Mano Jun'ichi Publishers : Crop Science Society of Japan | Taylor & Francis Date Issued : 2025-02-06
Creators : Hitaka Yukihiro | Isoyama Naohito | Tsuji Shunya | Honda Takeshi | Nakayama Yuki | Yamaguchi Mitsuhiro | Nakamura Kimihiko | Hirata Hiroshi | Shiraishi Koji | Asagiri Masataka Publishers : Elsevier Date Issued : 2024-05-21
Creators : Niyonzima Yvan Bienvenu | Asato Yuuki | Murakami Tomoaki | Kadokawa Hiroya Publishers : CSIRO Publishing
Creators : Fukui Shogo Publishers : Springer Nature Date Issued : 2024-06-06
Understanding of central nervous system mechanisms underlying age-related infertility remains limited. Fibril α-synuclein, distinct from its monomeric form, is implicated in age-related diseases. Notably, fibril α-synuclein spreads among neurons, similar to prions, from damaged old neurons in cortex and hippocampus to healthy neurons. However, less is known whether α-synuclein propagates into oxytocin neurons, which play crucial roles in reproduction. We compared α-synuclein expression in the oxytocin neurons in suprachiasmatic nucleus (SCN), supraoptic nucleus (SON), paraventricular hypothalamic nucleus (PVN), and posterior pituitary (PP) gland of healthy heifers and aged cows to determine its role in age-related infertility. We analyzed mRNA and protein expression, along with Congo red histochemistry and fluorescent immunohistochemistry for oxytocin and α-synuclein, followed by confocal microscopy with Congo red staining. Both mRNA and protein expressions of α-synuclein were confirmed in the bovine cortex, hippocampus, SCN, SON, PVN, and PP tissues. Significant differences in α-synuclein mRNA expressions were observed in the cortex and hippocampus between young heifers and old cows. Western blots showed five bands of α-synuclein, probably reflecting monomers, dimers, and oligomers, in the cortex, hippocampus, SCN, SON, PVN, and PP tissues, and there were significant differences in some bands between the young heifers and old cows. Bright-field and polarized light microscopy did not detect obvious amyloid deposition in the aged hypothalami; however, higher-sensitive confocal microscopy unveiled strong positive signals for Congo red and α-synuclein in oxytocin neurons in the aged hypothalami. α-synuclein was expressed in oxytocin neurons, and some differences were observed between young and old hypothalami.
Creators : Kadokawa Hiroya Publishers : The Society for Reproduction and Development Date Issued : 2024
Creators : Maruyama Mizuki | Ushine Nana | Watanabe Yukiko | Ishii Chihiro | Saito Keisuke | Sakai Hidefumi | Kuritani Takeshi | Doya Rio | Ogasawara Kohei | Ikenaka Yoshinori | Yohannes Yared Beyene | Ishizuka Mayumi | Nakayama Shouta M.M. Publishers : Elsevier Date Issued : 2024-05-15
A discrete Bayes decision rule and its application to personalized medicine
The journal of reliability engineering association of Japan Volume 45 Issue 6
本稿では、まず人工知能の根幹に係る一般パターン認識の問題を明らかにするとともに、その解決に有用な統計的パターン認識とそれを発展させた離散Bayes識別則を概説する。次に離散Bayes識別則の個別化医療への応用としての診断・予測問題と創薬における治験問題に言及する。
Creators : Hamamoto Yoshihiko Publishers : Reliability Engineering Association of Japan Date Issued : 2023-11
Context: Ethanolamine plasmalogens (EPls) and choline plasmalogens (CPls) are classes of ethanolamine ether phospholipids (ePE) or choline ether phospholipids (ePC), respectively. EPls play crucial roles in maternal and breastfed infant bodies and stimulate gonadotropin secretion by gonadotrophs. Aims: To estimate changes in and importance of plasma concentrations of EPls and CPls, utilizing newly developed enzymatic fluorometric assays for ePE and ePC in postpartum Holstein cows. Methods: Plasma samples were collected 3 weeks before expected parturition until approximately 8 weeks after parturition (16 primiparous and 38 multiparous cows) for analysis. Key results: Plasma concentrations of ePE and ePC, most of which are plasmalogens, declined before and increased after parturition and stabilised near the day of the first postpartum ovulation (1stOV). From weeks 2 to 3 after parturition, third-parity cows exhibited ePE concentrations that were higher than those of other parity cows. The days from parturition to 1stOV correlated with days from parturition to conception. On the day of 1stOV, milk yield correlated with plasma concentration of both ePE and ePC, while ePC concentration correlated negatively with milk fat percentage. At the early luteal phase after 1stOV, plasma ePE concentration correlated with plasma anti-Müllerian hormone concentration (r = 0.39, P < 0.01), and plasma ePC concentration correlated with plasma follicle-stimulating hormone concentration (r = 0.43, P < 0.01). Conclusion: The concentrations of ePE and ePC changed dramatically around parturition and 1stOV, and then the concentrations correlated with the important parameters. Implications: The blood plasmalogen may play important roles in postpartum dairy cows.
Creators : Saito Risa | Kubo Tomoaki | Wakatsuki Takuji | Asato Yuuki | Tanigawa Tamako | Kotaniguchi Miyako | Hashimoto Maki | Kitamura Shinichi | Kadokawa Hiroya Publishers : CSIRO Publishing Date Issued : 2023-07-19
McTaggart’s paradox and his A-theory and B-theory are basic notions in the contemporary philosophy of time. It is well known that the paradox was introduced by McTaggart’s paper called “The Unreality of Time” published in 1908, so that it has a one-hundred-year history. As for A-theory and B-theory, in contrast, McTaggart himself didn’t consider both of them at all. The notions of A-theory and B-theory came much later, 60 years after the paradox. Moreover, they had not been as popularized as they are today until quite recently, at least after the 1990s. This paper aims to trace the origin of the notions of A-theory and B-theory and show how the debates behind them, especially objections to “spatialising time,” form the notions.
Creators : 小山 虎 Publishers : 日本科学哲学会 Date Issued : 2023-03-31
Analytic philosophy in Japan since 2000
Asian Journal of Philosophy Volume 1 Issue 2
Since its inception, analytic philosophy has failed to attain dominance in Japan. However, the 21st century has seen analytic philosophy gain traction among Japanese philosophers. This paper, which examines the status quo of analytic philosophy in Japan since 2000, consists of two parts. The first part deals primarily with organizations—specifically, relevant associations, journals, conferences, universities, and publishers are illustrated. The second part explores key works in each area—namely, philosophy of science, philosophy of language, philosophy of logic and mathematics, philosophy of mind, and metaphysics. Key works in other areas are also briefly addressed.
Creators : 小山 虎 Publishers : Springer Date Issued : 2022-12
China has been struggling with waste classification for decades, even after the mandatory implementation of relevant policy in 2017. However, the causes of the failing performance of waste classification in developing countries attract little scholarly attention. A recent literature review also identified a failure to classify waste in developing countries, noting that its causes have attracted little scholarly interest. In this paper, we would like to examine the current situation and issues of policies for classifying household waste in China's urban sector. In this paper, we conducted a questionnaire survey of residents in Changsha City, Hunan Province, examined their awareness of waste classification, classifying behavior, and their awareness of paying for waste reduction, elucidated the factors that affect them, and estimated the amount of willing to pay (WTP) for waste reduction. In this paper, endogenous factors are more significant influencing behaviors than exogenous factors.
Creators : Liu Sicai | Chen Li-chun Publishers : The Economic Society of Yamaguchi University Date Issued : 2022-11-30
Imitation is simple behavior which uses successful actions of others in order to deal with one’s own problems. Because success of imitation generally depends on whether profit of an imitating agent coincides with those of other agents or not, game theory is suitable for specifying situations where imitation can be successful. One of the concepts describing successfulness of imitation in repeated two-player symmetric games is unbeatability. For infinitely repeated two-player symmetric games, a necessary and sufficient condition for some imitation strategy to be unbeatable was specified. However, situations where imitation can be unbeatable in multi-player games are still not clear. In order to analyze successfulness of imitation in multi-player situations, here we introduce a class of totally symmetric games called unexploitable games, which is a natural extension of two-player symmetric games without exploitation cycles. We then prove that, for infinitely repeated unexploitable games, there exist unbeatable imitation strategies. Furthermore, we also prove that, for infinitely repeated non-trivial unexploitable games, there exist unbeatable zero-determinant strategies, which unilaterally enforce some relationships on payoffs of players. These claims are demonstrated in the public goods game, which is the simplest unexploitable game. These results show that there are situations where imitation is unbeatable even in multi-player games.
Creators : Ueda Masahiko Publishers : IEEE Date Issued : 2023-01-10
編集後記
村上春樹とアダプテーション研究 Volume 1
Creators : Yamane Yumie Publishers : 村上春樹とアダプテーション研究会 Date Issued : 2023-01-31
Creators : 阿部 翔太 Publishers : 村上春樹とアダプテーション研究会 Date Issued : 2023-01-31
Creators : ダルミ カタリン Publishers : 村上春樹とアダプテーション研究会 Date Issued : 2023-01-31
Related Journals
山口医学 Volume 9 Issue 5 54 山口医学 Volume 9 Issue 6 48 山口医学 Volume 9 Issue 4 47 山口医学 Volume 9 Issue 1 43 山口医学 Volume 9 Issue 3 42 山口医学 Volume 9 Issue 2 42 山口医学 Volume 11 Issue 2 35 山口医学 Volume 10 Issue 3 31 山口医学 Volume 6 Issue 4 29 山口医学 Volume 6 Issue 3 26 山口医学 Volume 10 Issue 4 26 山口医学 Volume 7 Issue 4 26 山口医学 Volume 10 Issue 2 23 山口医学 Volume 10 Issue 1 22 山口臨床医学 Volume 3 Issue 2-4 22 山口医学 Volume 7 Issue 5 21 The journal of Yamaguchi area studies Volume 14 21 Journal of East Asian studies Volume 18 21 山口医学 Volume 33 Issue 6 19 山口医学 Volume 7 Issue 3 19 The journal of Yamaguchi area studies Volume 9 19 Journal of East Asian studies Volume 13 19 Journal of East Asian studies Volume 14 19 山口医学 Volume 7 Issue 2 18 山口医学 Volume 31 Issue 6 18 山口医学 Volume 40 Issue 1 18 山口医学 Volume 6 Issue 2 17 山口医学 Volume 39 Issue 2 17 山口臨床医学 Volume 2 Issue 1 17 山口医学 Volume 33 Issue 4 16 山口医学 Volume 39 Issue 3 16 Journal of East Asian studies Volume 15 16 山口医学 Volume 5 Issue 2 15 山口医学 Volume 5 Issue 3 15 山口医学 Volume 5 Issue 1 15 山口医学 Volume 30 Issue 4 15 山口医学 Volume 29 Issue 4 15 アジアの歴史と文化 Volume 16 15 山口医学 Volume 29 Issue 3 15 山口医学 Volume 19 Issue 2-4 15 Journal of East Asian studies Volume 11 15 アジアの歴史と文化 Volume 18 15 山口医学 Volume 12 Issue 3 14 山口医学 Volume 20 Issue 2-4 14 山口医学 Volume 28 Issue 3-4 14 山口医学 Volume 39 Issue 1 14 山口医学 Volume 16 Issue 2 14 山口医学 Volume 18 Issue 3-4 14 Journal of East Asian studies Volume 16 14 山口医学 Volume 40 Issue 3 14
Show More
Show Less