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Effect of monoclonal antibody against tnf-alfa on noise-induced inner ear damage

Medical Science & Innovation Volume 71 Issue 1-2 Page 35-43
published_at 2024-06
A050071000104
[fulltext] 1.97 MB
Title
Effect of monoclonal antibody against tnf-alfa on noise-induced inner ear damage
Abstract
This study investigated the potential of adalimumab (ADA), a monoclonal antibody targeting TNF-alfa, to protect the inner ear from intense sound exposure, given that inflammatory cytokines, including TNF-alfa, are linked to hearing loss in acoustic disorders. In this study, adalimumab was administered to mice, and its effect on the inner ear was assessed. We examined the translocation of ADA to the inner ear and its ototoxicity and impact on acoustic exposure. The results showed that adalimumab partially reached the cochlea after administration but increased the susceptibility to acoustic exposure, resulting in higher hair cell loss in the inner ear. While TNF-alfa had been considered a potential therapeutic target, the results suggested that excessive TNF-alfa suppression could harm the inner ear. We acknowledged some limitations, such as the use of adalimumab instead of an anti-mouse TNF-alfa antibody and the need to explore the suppression of other cytokines for better inner ear protection. In conclusion, adalimumab administration was found to increase the inner earʼs susceptibility to acoustic exposure, potentially leading to more significant hair cell damage, possibly due to excessive TNF-alfa suppression
Creators 山本 陽平
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Sugahara Kazuma
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Tsuda Junko
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Hashimoto Makoto
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Yamashita Hiroshi
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Source Identifiers
Creator Keywords
TNF-alfa noise trauma Adalimumab mouse
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2024-06
File Version Version of Record
Access Rights open access
Schools 大学院医学系研究科