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The purpose of this study was to compare demographic trends in the aging of the Japanese and Brazilian populations on the basis of health indicator data collected by the statistics bureaus of the Japanese and Brazilian governments. The demographic and health indicator data from surveys by the Statistics Bureaus of the Japanese and Brazilian governments and other sources were obtained from websites. The data showed that Japan has an aging population, that the number of elderly persons in Japan is increasing and that the Government of Japan has a plan to address future demands for health resources by this aging population, whereas Brazil has a rapidly population aging but no plan for its future health services. Brazil may need to increase the number of hospitals and hospital beds and develop a medical care plan for the elderly within its Unified Health System.
Creators : Sendo Eliane Satie Inoue Masaiwa Laskar MS Harada Noriaki Publishers : Yamaguchi University School of Medicine
Histopathological and immunohistochemical studies were conducted to investigate the local existence and distribution of mast cells, fibroblasts or dendritic cells, and myofibroblasts in scleroderma, while paying particular attention to the interstices around the adnexa. The skin tissues in 15 cases of systemic scleroderma were classified histopathologically into three stages: early, fully developed, and late stage. Mesenchymal cells were distinguished immunohistochemically by 6 markers: tryptase, CD34, factor XIIIa, alpha smooth muscle actin (αSMA), vimentin, and desmin. In scleroderma, there was an increase in the number of tryptase-positive mast cells in the interstices around the adnexa. With no relation to the interstitial sites, there was a significant decrease in the number of CD34-positive cells in the late stage, and a significant increase in αSMA-positive cells in the fully developed stage, but a decrease in the late stage. Results of the present study brought about the following new findings: it was only in the mast cells that there was a significant difference in the cell distribution between the interstices around the adnexa and the interstices in non-adnexal sites. Secondly, it was suggested that mast cells, CD34-positive dendritic cells, and αSMA-positive myofibroblasts were involved in the fibrosis and shrinkage or disappearance of the adnexa when scleroderma developed.
Creators : Yokoyama Emi Publishers : Yamaguchi University School of Medicine
Hepatocellular carcinoma (HCC) has a poor prognosis even after curative surgery, due to the high frequency of early intrahepatic recurrence (IHR). Conventional staging systems are almost completely inadequate, and need to be complemented by novel tools. To this end, many investigators have performed DNA microarray analysis on the basis of genome-wide information. However, so far, few studies have been able to truly account for the clinical efficacy of DNA microarray analysis in HCC. To address this dilemma, we used a supervised learning method with information of 7070 genes from 33 HCC samples, to construct a 12-gene predictor for early IHR, and then evaluated its predictive performance in 27 independent HCC samples. Our 12-gene predictor correctly predicted early IHR or non-recurrence in 25 (93%) of the 27 independent samples. This predictive value is higher than that of any other system currently available, suggesting that our system can serve as a robust tool for accurate prediction of early IHR of HCC. I emphasize in this mini-review that, although there are some technical issues to resolve prior to clinical use, DNA microarray technology can provide molecular basis to initiate “bench to bedside” translation, which cannot be easily reached with other methods.
Creators : Iizuka Norio Publishers : Yamaguchi University School of Medicine
Application of cell therapy using stem cell into intractable diseases has been noted as the medicine in the next generation taking the place of organ transplantation. Bone marrow cells have been focused as a candidate of the source of this therapy. Liver failure is a terminal state of all advanced liver diseases and thousands of patients are dying of decompensated liver cirrhosis in every year in Japan. Liver transplantation must be the strongest weapon to relieve those patients. However, particularly in Japan, liver transplantation has not been popularized. In this sense, we thought of autologous bone marrow cells transplantation for decompensated liver cirrhosis. Basic studies using animal model revealed that transplanted bone marrow cells into syngenic mouse suffering from liver cirrhosis migrated into the damaged liver and transdifferentiated to the hepatocytes. Based upon the animal studies, clinical trial of this new cell therapy supported by the Ministry of Health, Labor and Welfare is ongoing. It is early to estimate this therapy. However, free from liver failure has been observed in some cases.
Creators : Okita Kiwamu Sakaida Isao Terai Shuji Yamamoto Naoki Omori Kaoru Ishikawa Tsuyoshi Aoyama Kouji Shinoda Koh Hamamoto Yoshihiko Publishers : Yamaguchi University School of Medicine
山口医学 Volume 56 Issue 2 pp. 37 - 41
published_at 2007-04-30
Creators : Harada Eijiro Shiraishi Kei Enoki Tadahiko Noshima Shinji Hamano Kimikazu Publishers : 山口大学医学会
山口医学 Volume 53 Issue 3 pp. 133 - 137
published_at 2004-06-30
Creators : Mori Naohide Sakamoto Kazuhiko Tamesa Takao Okada Toshimasa Takemoto Norikazu Hashimoto Kiichirou Tangoku Akira Oka Masaaki Publishers : 山口大学医学会
山口医学 Volume 53 Issue 2 pp. 109 - 114
published_at 2004-04-30
Creators : Kawano Kazuaki Katoh Tomoe Yagi Takaharu Hirata Ken Hayashi Masataro Seyama Atsushi Oga Atsunori Publishers : 山口大学医学会
山口医学 Volume 53 Issue 1 pp. 55 - 65
published_at 2004-02-29
Creators : Murata Yoichiro Publishers : 山口大学医学会
山口医学 Volume 53 Issue 1 pp. 47 - 54
published_at 2004-02-29
Creators : Terasaki Yutaka Publishers : 山口大学医学会
山口医学 Volume 53 Issue 1 pp. 39 - 45
published_at 2004-02-29
Creators : Moriwaki Toru Publishers : 山口大学医学会
山口医学 Volume 53 Issue 1 pp. 21 - 27
published_at 2004-02-29
Creators : Fujii Kenzo Publishers : 山口大学医学会
山口医学 Volume 53 Issue 1 pp. 9 - 19
published_at 2004-02-29
Creators : Sugino Norihiro Publishers : 山口大学医学会
山口医学 Volume 53 Issue 1 pp. 5 - 7
published_at 2004-02-29
Creators : Fujimiya Tatsuya Publishers : 山口大学医学会
山口医学 Volume 55 Issue 5 pp. 167 - 172
published_at 2006-10-31
Creators : Matsumoto Kanako Matsuda Masako Miyata Fumi Karahi Sayaka Ichihara Kiyoshi Hirano Hitoshi Publishers : 山口大学医学会
山口医学 Volume 55 Issue 2-3 pp. 61 - 65
published_at 2006-06-30
Creators : Mitsuoka Kouji Mano Takamitsu Okafuji Masaki Yoshimura Tatsuo Horinaga Daiju Fukuda Teruyo Ueyama Yoshiya Publishers : 山口大学医学会
山口医学 Volume 55 Issue 2-3 pp. 55 - 60
published_at 2006-06-30
Creators : Yamazaki Hideo Publishers : 山口大学医学会
山口医学 Volume 54 Issue 1 pp. 5 - 11
published_at 2005-02-28
Creators : Kanda Takashi Publishers : 山口大学医学会
山口医学 Volume 53 Issue 6 pp. 279 - 289
published_at 2004-12-31
Creators : Nakamura Ippei Okuda Masayuki Kage Haruko Kunitsugu Ichiro Sugiyama Shinichi Fujii Akihiro Matsubara Asako Tan Nobusuke Hobara Tatsuya Publishers : 山口大学医学会
山口医学 Volume 52 Issue 6 pp. 263 - 273
published_at 2003-12-31
Creators : Kaneko Noboru Publishers : 山口大学医学会
山口医学 Volume 52 Issue 5 pp. 189 - 194
published_at 2003-10-31
Creators : Numa Fumitaka Sueoka Kohtaro Nawata Shugo Sumie Masahiro Kawasaki Keiko Umayahara Kenji Ogata Hidenobu Sugino Norihiro Publishers : 山口大学医学会
山口医学 Volume 52 Issue 5 pp. 183 - 187
published_at 2003-10-31
Creators : Miyazaki Mutsuko Taguchi Akihiko Sakuragi Shizu Shinohara Kenji Inoue Yasushi Publishers : 山口大学医学会
山口医学 Volume 52 Issue 6 pp. 297 - 302
published_at 2003-12-31
Creators : Nakazora Tatsuki Yanai Hideo Nakamura Youhei Kitou Tomoko Okita Kiwamu Matsumoto Yusuke Oka Masaaki Sasaki Kousuke Publishers : 山口大学医学会
山口医学 Volume 52 Issue 6 pp. 285 - 295
published_at 2003-12-31
Creators : Kuriyama Ryutaro Publishers : 山口大学医学会
山口医学 Volume 52 Issue 1-2 pp. 7 - 11
published_at 2003-04-30
Creators : Nobumoto Masaaki Matsubara Toshiro Watanabe Yoshifumi Publishers : 山口大学医学会
山口医学 Volume 52 Issue 1-2 pp. 5 - 6
published_at 2003-04-30
Creators : Nakamura Syoji Publishers : 山口大学医学会
山口医学 Volume 52 Issue 1-2 pp. 3 - 4
published_at 2003-04-30
Creators : Morimatsu Mitsunori Publishers : 山口大学医学会
山口医学 Volume 51 Issue 4 pp. 113 - 117
published_at 2002-08-31
Creators : Kuramitsu Yasuhiro Fujimoto Masanori Nakamura Kazuyuki Publishers : 山口大学医学会
山口医学 Volume 51 Issue 3 pp. 61 - 62
published_at 2002-06-30
Creators : Iwata Takako Publishers : 山口大学医学会
山口医学 Volume 51 Issue 2 pp. 41 - 45
published_at 2002-04-30
Creators : Ita Masamichi Ishihara Yoshihisa Fukuda Kazuhiko Mitsuoka Kouji Okafuji Masaki Publishers : 山口大学医学会
山口医学 Volume 51 Issue 2 pp. 39 - 40
published_at 2002-04-30
Creators : Suga Kazuyoshi Publishers : 山口大学医学会
山口医学 Volume 50 Issue 3 pp. 645 - 650
published_at 2001-06-30
Creators : Noshima Shinji Nakayashiki Chizuru Fujii Masakazu Inokuchi Toshihiro Kobayashi Tetsurou Enoki Tadahiko Publishers : 山口大学医学会
山口医学 Volume 50 Issue 2 pp. 603 - 608
published_at 2001-04-30
Creators : Miyamoto Koji Publishers : 山口大学医学会
山口医学 Volume 49 Issue 6 pp. 519 - 525
published_at 2000-12-30
Creators : Chikama Tai-ichiro Publishers : 山口大学医学会
山口医学 Volume 49 Issue 5 pp. 497 - 501
published_at 2000-10-31
Creators : Nishina Sohji Hino Keisuke Katoh Yoshiharu Okita Kiwamu Publishers : 山口大学医学会
山口医学 Volume 51 Issue 5 pp. 169 - 170
published_at 2002-10
Creators : 沖田 極 Publishers : 山口大学医学会
山口医学 Volume 51 Issue 5 pp. 157 - 162
published_at 2002-10
Creators : Takahashi Mutsuo Publishers : 山口大学医学会
山口医学 Volume 51 Issue 4 pp. 125 - 129
published_at 2002-08-31
Creators : Fujii Masakazu Nishida Kazuya Takenaka Hiroaki Nishida Ken-ichi Publishers : 山口大学医学会
山口医学 Volume 49 Issue 4 pp. 439 - 447
published_at 2000-08-31
Creators : Takeuchi Hiroaki Publishers : 山口大学医学会
山口医学 Volume 49 Issue 1-2 pp. 349 - 353
published_at 2000-04-30
Creators : Sugi Kazuro Sato Yasushi Takaki Akira Nakashima Kazuki Miyagawa Shoichi Publishers : 山口大学医学会
山口医学 Volume 49 Issue 1-2 pp. 343 - 348
published_at 2000-04-30
Creators : Okuda Masayuki Kunitsugu Ichiro Kanayama Masako Tanaka Aiko Sugi Yoko Mitsuoka Setsuko Hobara Tatsuya Publishers : 山口大学医学会
山口医学 Volume 49 Issue 4 pp. 165 - 172
published_at 1999-08
Creators : Tanaka Aiko Sugi Yoko Kanemura Masako Nakao Hisako Azuma Reiko Ikeguchi Keikan Okuda Masayuki Ri Keiei Kobayashi Haruo Hobora Tatsuya Publishers : 山口大学医学会
山口医学 Volume 48 Issue 4 pp. 159 - 164
published_at 1999-08
Creators : Sugahara Kazuma Okinaka Yoshihiko Imate Yuji Shimogori Hiroaki Ogata Yoichi Noguchi Fumiko Fukui Kazuko Yamashita Hiroshi Fujinami Tomoyuki Hasegawa Toshifumi Publishers : 山口大学医学会
山口医学 Volume 53 Issue 3 pp. 153 - 157
published_at 2004-06-30
Creators : Hahashi Eiko Mano Takamitsu Miizugaki Yuzo Okafuji Masaki Uchida Kenichiro Ueyama Yoshiya Publishers : 山口大学医学会
山口医学 Volume 53 Issue 3 pp. 145 - 151
published_at 2004-06-30
Creators : Hashimoto Shinichi Harada Katsunori Nohara Hiroaki Saitou Yuki Higaki Shingo Yanai Hideo Yoshida Tomoharu Okita Kiwamu Publishers : 山口大学医学会
山口医学 Volume 48 Issue 6 pp. 255 - 261
published_at 1999-12
Creators : ishikawa Tsuyoshi Tamura Suguru Kondo Satoshi Okita Kiwamu Publishers : 山口大学医学会
山口医学 Volume 48 Issue 1 pp. 1 - 2
published_at 1999-02
Creators : Kayano Kozo Sakaida Isao Okita Kiwamu Publishers : 山口大学医学会
山口医学 Volume 47 Issue 6 pp. 197 - 202
published_at 1998-12
Creators : Adachi Atsushi Toshimitsu Hiroaki Shimoda Koji Uchiyama Tetsuji Murakami Takuo Publishers : 山口大学医学会
山口医学 Volume 47 Issue 5 pp. 143 - 148
published_at 1998-10
Creators : Muto Masahiko Publishers : 山口大学医学会
山口医学 Volume 47 Issue 4 pp. 117 - 128
published_at 1998-08
Creators : Morioka Hisashi Morioka Takayuki Inoue Motoshige Furutani Harushige Shigeta Kojiro Shinkai Yasushi Sasaki Terumasa Tatebayashi Kinichiro Miyashita Hiroshi Akao Shinji Murakami Takuo Tanaka Nobuyuki Publishers : 山口大学医学会
山口医学 Volume 47 Issue 4 pp. 109 - 115
published_at 1998-08
Creators : Kato Tomoe Minami Yoshihide Goura Hidenori Hamano Kimikazu Noda Hiroshi Fujimura Yoshihiko Esato Kensuke Mikamo Akihito Furukawa Syoichi Oda Tatsro Miyamoto Masaki Publishers : 山口大学医学会
山口医学 Volume 47 Issue 4 pp. 103 - 108
published_at 1998-08
Creators : Ito Haruhide Yamashita Katsuhiro Kato Syoichi Fujisawa Hirosuke Nishizaki Takafumi Kajiwara Koji Publishers : 山口大学医学会
山口医学 Volume 47 Issue 4 pp. 99 - 101
published_at 1998-08
Creators : Fukumoto Tetsuo O Gyokusetsu Hashimoto Noriko Tokuda Nobuko Sawada Tomoo Publishers : 山口大学医学会
山口医学 Volume 46 Issue 5 pp. 279 - 291
published_at 1997-10
Creators : Kubo Yoshhitsugu Okita Kiwamu Publishers : 山口大学医学会
山口医学 Volume 46 Issue 4 pp. 237 - 244
published_at 1997-08
Creators : Dairaku Koji Morikage Noriyasu Toyota Shuji Yoshimura Koichi Kuga Takayuki Fujioka Kentaro Kato Tomoe Fujimura Yoshihiko Zempo Nobuya Esato Kensuke Publishers : 山口大学医学会
山口医学 Volume 46 Issue 4 pp. 231 - 236
published_at 1997-08
Creators : Nakamura Hiroki Yanai Hideo Nishikawa Jyun Tokiyama Hiroshi Yoshida Tomoharu Tada Masahiro Okita Kiwamu Matsuno Yoko Takahashi Mutsuo Hoshii Yoshinobu Publishers : 山口大学医学会
山口医学 Volume 46 Issue 4 pp. 223 - 230
published_at 1997-08
Creators : Kobayashi Takayoshi Ushijima Itsuko Matsuda Yoshito Abe Masaaki Kawano Michihide Yamada Michio Publishers : 山口大学医学会
山口医学 Volume 46 Issue 3 pp. 173 - 178
published_at 1997-06
Creators : Itaya Miwa Mtayoshi Yasuttoshi Tamura Hisashi Ito Makoto Sumi Chieko Utada Kouji Publishers : 山口大学医学会
山口医学 Volume 46 Issue 3 pp. 165 - 171
published_at 1997-06
Creators : Miyahara Makoto Publishers : 山口大学医学会
山口医学 Volume 46 Issue 3 pp. 157 - 164
published_at 1997-06
Creators : Imate Yuji Endo Shiro Okami Kenji Takahashi Masahiro Publishers : 山口大学医学会
山口医学 Volume 46 Issue 2 pp. 139 - 146
published_at 1997-04
Creators : Takeda Komei Ariyoshi Koichi Kameda Naoko Shinohara Kenji Kamei Toshiaki Publishers : 山口大学医学会
山口医学 Volume 46 Issue 2 pp. 131 - 138
published_at 1997-04
Creators : Kaino Seiji Yanai Hideo Nakamura Hiroki Tokiyama Yu Nishiake Shin Kainou Miyuki Aikiyama Tetsuji Tada Masahiro Okita Kiwamu Takahashi Mutsuo Publishers : 山口大学医学会
山口医学 Volume 46 Issue 2 pp. 121 - 130
published_at 1997-04
Creators : Muto Masahiko Hirota Toru Shimizu Takahiro Tachino Hiroaki Mogami Satoshi Yasui Hiroo Ichimiya Makoto Nagai Hiroshi Nakano Jyunji Asagami Chidori Publishers : 山口大学医学会
山口医学 Volume 46 Issue 2 pp. 111 - 120
published_at 1997-04
Creators : Kawano Michihide Publishers : 山口大学医学会
山口医学 Volume 46 Issue 2 pp. 103 - 109
published_at 1997-04
Creators : Azuno Yoichi Kaneko Toshio Sato Yutaka Nishimura Manabu Seguchi Masato Yoshida Takeshi Yujiri Toshiaki Kamei Shinji Zaitsu Yuzuru Inoue Yusuke Publishers : 山口大学医学会
山口医学 Volume 46 Issue 2 pp. 95 - 102
published_at 1997-04
Creators : Shimizu Takahiro Muto Masahiko Furumoto Reiko Nakano Jyunji Yasui Hiroo Yasui Yuki Tateno Hiroaki Murakami Tomoyuki Asagami Chidori Publishers : 山口大学医学会
山口医学 Volume 46 Issue 1 pp. 23 - 28
published_at 1997-02
Creators : Furumoto Hiroko Publishers : 山口大学医学会
山口医学 Volume 46 Issue 1 pp. 15 - 22
published_at 1997-02
Creators : Nibu Kimio Publishers : 山口大学医学会
山口医学 Volume 45 Issue 6 pp. 429 - 434
published_at 1996-12
Creators : Furunaga Akihiko Kawamura Tsutomu Nakayama Tomita Fujii Yasuhiro Hiromoto Mitsuyuki Esato Kensuke Publishers : 山口大学医学会
山口医学 Volume 45 Issue 6 pp. 401 - 408
published_at 1996-12
Creators : Toyota Shuji Publishers : 山口大学医学会
山口医学 Volume 45 Issue 6 pp. 391 - 399
published_at 1996-12
Creators : Matsuo Takuhisa Publishers : 山口大学医学会
山口医学 Volume 53 Issue 4-5 pp. 207 - 213
published_at 2004-10-31
Creators : Nogaki Hiroshi Publishers : 山口大学医学会
山口医学 Volume 45 Issue 1 pp. 1 - 10
published_at 1996-02
Creators : Takahashi Masahiro Publishers : 山口大学医学会
山口医学 Volume 44 Issue 6 pp. 395 - 398
published_at 1995-12
Creators : Fukusako Toshihiro Negoro Kiyoshi Tanaka Shin-ichiro Morimatsu Mitsunori Publishers : 山口大学医学会
山口医学 Volume 44 Issue 6 pp. 389 - 394
published_at 1995-12
Creators : Okinaka Yoshihiko Masumitsu Youichi Ono Nobuchika Ogata Yoichi Takahashi Masahiro Publishers : 山口大学医学会
山口医学 Volume 44 Issue 6 pp. 355 - 365
published_at 1995-12
Creators : Nakajima Kazutaka Publishers : 山口大学医学会
山口医学 Volume 44 Issue 6 pp. 319 - 327
published_at 1995-12
Creators : Maeda Yoshitaka Publishers : 山口大学医学会
山口医学 Volume 44 Issue 5 pp. 259 - 266
published_at 1995-10
Creators : Nagasawa Takaaki Isoyama Riichiro Kinoshita Kihoko Ochi Mayumi Ueda Jyunko Iwata Takako Publishers : 山口大学医学会
山口医学 Volume 44 Issue 5 pp. 253 - 258
published_at 1995-10
Creators : Nishimura Yukiko Sasabe Fujio Fukusako Toshihiro Negoro Kiyoshi Nogaki Hiroshi Morimitsu Mitsunori Publishers : 山口大学医学会
山口医学 Volume 44 Issue 4 pp. 201 - 212
published_at 1995-08
Creators : Saeki Toshihiro Publishers : 山口大学医学会
山口医学 Volume 44 Issue 4 pp. 195 - 199
published_at 1995-08
Creators : Ueda Kazuhiko Sugi Kazuro Kaneda Yoshikazu Nawata Sumihiko Esato Kensuke Publishers : 山口大学医学会
山口医学 Volume 48 Issue 3 pp. 79 - 83
published_at 1999-06
Creators : Ri Teirin Publishers : 山口大学医学会