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Immunohistochemical evaluation of dermal mesenchymal cells in relation to the development of scleroderma

The bulletin of the Yamaguchi Medical School Volume 52 Issue 3-4 Page 43-53
published_at 2005-12
A020052000304
[fulltext] 1.1 MB
Title
Immunohistochemical evaluation of dermal mesenchymal cells in relation to the development of scleroderma
Abstract
Histopathological and immunohistochemical studies were conducted to investigate the local existence and distribution of mast cells, fibroblasts or dendritic cells, and myofibroblasts in scleroderma, while paying particular attention to the interstices around the adnexa. The skin tissues in 15 cases of systemic scleroderma were classified histopathologically into three stages: early, fully developed, and late stage. Mesenchymal cells were distinguished immunohistochemically by 6 markers: tryptase, CD34, factor XIIIa, alpha smooth muscle actin (αSMA), vimentin, and desmin. In scleroderma, there was an increase in the number of tryptase-positive mast cells in the interstices around the adnexa. With no relation to the interstitial sites, there was a significant decrease in the number of CD34-positive cells in the late stage, and a significant increase in αSMA-positive cells in the fully developed stage, but a decrease in the late stage. Results of the present study brought about the following new findings: it was only in the mast cells that there was a significant difference in the cell distribution between the interstices around the adnexa and the interstices in non-adnexal sites. Secondly, it was suggested that mast cells, CD34-positive dendritic cells, and αSMA-positive myofibroblasts were involved in the fibrosis and shrinkage or disappearance of the adnexa when scleroderma developed.
Creators Yokoyama Emi
Source Identifiers [PISSN] 0513-1812 [EISSN] 2436-696X
Creator Keywords
scleroderma mast cell dermal dendritic cell CD34 αSMA
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2005-12
File Version Version of Record
Access Rights open access
Schools 医学部