コンテンツメニュー
Id (<span class="translation_missing" title="translation missing: en.view.desc">Desc</span>)
The purpose of this study was to compare demographic trends in the aging of the Japanese and Brazilian populations on the basis of health indicator data collected by the statistics bureaus of the Japanese and Brazilian governments. The demographic and health indicator data from surveys by the Statistics Bureaus of the Japanese and Brazilian governments and other sources were obtained from websites. The data showed that Japan has an aging population, that the number of elderly persons in Japan is increasing and that the Government of Japan has a plan to address future demands for health resources by this aging population, whereas Brazil has a rapidly population aging but no plan for its future health services. Brazil may need to increase the number of hospitals and hospital beds and develop a medical care plan for the elderly within its Unified Health System.
Creators : Sendo Eliane Satie Inoue Masaiwa Laskar MS Harada Noriaki Publishers : Yamaguchi University School of Medicine
Histopathological and immunohistochemical studies were conducted to investigate the local existence and distribution of mast cells, fibroblasts or dendritic cells, and myofibroblasts in scleroderma, while paying particular attention to the interstices around the adnexa. The skin tissues in 15 cases of systemic scleroderma were classified histopathologically into three stages: early, fully developed, and late stage. Mesenchymal cells were distinguished immunohistochemically by 6 markers: tryptase, CD34, factor XIIIa, alpha smooth muscle actin (αSMA), vimentin, and desmin. In scleroderma, there was an increase in the number of tryptase-positive mast cells in the interstices around the adnexa. With no relation to the interstitial sites, there was a significant decrease in the number of CD34-positive cells in the late stage, and a significant increase in αSMA-positive cells in the fully developed stage, but a decrease in the late stage. Results of the present study brought about the following new findings: it was only in the mast cells that there was a significant difference in the cell distribution between the interstices around the adnexa and the interstices in non-adnexal sites. Secondly, it was suggested that mast cells, CD34-positive dendritic cells, and αSMA-positive myofibroblasts were involved in the fibrosis and shrinkage or disappearance of the adnexa when scleroderma developed.
Creators : Yokoyama Emi Publishers : Yamaguchi University School of Medicine
Hepatocellular carcinoma (HCC) has a poor prognosis even after curative surgery, due to the high frequency of early intrahepatic recurrence (IHR). Conventional staging systems are almost completely inadequate, and need to be complemented by novel tools. To this end, many investigators have performed DNA microarray analysis on the basis of genome-wide information. However, so far, few studies have been able to truly account for the clinical efficacy of DNA microarray analysis in HCC. To address this dilemma, we used a supervised learning method with information of 7070 genes from 33 HCC samples, to construct a 12-gene predictor for early IHR, and then evaluated its predictive performance in 27 independent HCC samples. Our 12-gene predictor correctly predicted early IHR or non-recurrence in 25 (93%) of the 27 independent samples. This predictive value is higher than that of any other system currently available, suggesting that our system can serve as a robust tool for accurate prediction of early IHR of HCC. I emphasize in this mini-review that, although there are some technical issues to resolve prior to clinical use, DNA microarray technology can provide molecular basis to initiate “bench to bedside” translation, which cannot be easily reached with other methods.
Creators : Iizuka Norio Publishers : Yamaguchi University School of Medicine
Application of cell therapy using stem cell into intractable diseases has been noted as the medicine in the next generation taking the place of organ transplantation. Bone marrow cells have been focused as a candidate of the source of this therapy. Liver failure is a terminal state of all advanced liver diseases and thousands of patients are dying of decompensated liver cirrhosis in every year in Japan. Liver transplantation must be the strongest weapon to relieve those patients. However, particularly in Japan, liver transplantation has not been popularized. In this sense, we thought of autologous bone marrow cells transplantation for decompensated liver cirrhosis. Basic studies using animal model revealed that transplanted bone marrow cells into syngenic mouse suffering from liver cirrhosis migrated into the damaged liver and transdifferentiated to the hepatocytes. Based upon the animal studies, clinical trial of this new cell therapy supported by the Ministry of Health, Labor and Welfare is ongoing. It is early to estimate this therapy. However, free from liver failure has been observed in some cases.
Creators : Okita Kiwamu Sakaida Isao Terai Shuji Yamamoto Naoki Omori Kaoru Ishikawa Tsuyoshi Aoyama Kouji Shinoda Koh Hamamoto Yoshihiko Publishers : Yamaguchi University School of Medicine
山口医学 Volume 68 Issue 4 pp. 167 - 169
published_at 2019-12-11
Publishers : 山口大学医学会
山口医学 Volume 68 Issue 1 pp. 5 - 12
published_at 2019-03-01
Creators : Hazama Shoichi Publishers : 山口大学医学会
山口医学 Volume 67 Issue 3 pp. 179 - 181
published_at 2018-10-01
Publishers : 山口大学医学会
山口医学 Volume 67 Issue 3 pp. 175 - 177
published_at 2018-10-01
Publishers : 山口大学医学会
山口医学 Volume 66 Issue 4 pp. 243 - 245
published_at 2017-10-06
Publishers : 山口大学医学会
山口医学 Volume 66 Issue 3 pp. 205 - 206
published_at 2017-08-01
Publishers : 山口大学医学会
山口医学 Volume 66 Issue 1 pp. 69 - 70
published_at 2017-02-01
Publishers : 山口大学医学会
山口医学 Volume 65 Issue 3 pp. 153 - 155
published_at 2016-08-01
Publishers : 山口大学医学会
山口医学 Volume 65 Issue 3 pp. 149 - 151
published_at 2016-08-01
Publishers : 山口大学医学会
山口医学 Volume 64 Issue 4 pp. 297 - 299
published_at 2015-11-01
Publishers : 山口大学医学会
山口医学 Volume 64 Issue 4 pp. 291 - 295
published_at 2015-11-01
Publishers : 山口大学医学会
山口医学 Volume 64 Issue 3 pp. 243 - 245
published_at 2015-08-01
Publishers : 山口大学医学会
山口医学 Volume 64 Issue 3 pp. 191 - 197
published_at 2015-08-01
Creators : Fukuda Yoshiharu Nakamura Hiroshi Segawa Makoto Abe Masaaki Taguchi Akihiko Miyazaki Mutsuko Publishers : 山口大学医学会
山口医学 Volume 64 Issue 1 pp. 25 - 34
published_at 2015-02-01
Creators : Fukuda Yoshiharu Nakamura Hiroshi Segawa Makoto Harada Tadanari Taguchi Akihiko Abe Masaaki Publishers : 山口大学医学会
Anticancer Res Volume 34 Issue 9 pp. 4807 - 4811
published_at 2014-11-01
Creators : Nawata Junya Kuramitsu Yasuhiro Wang Yufeng Kitagawa Takao Tokuda Kazuhiro Baron Byron Akada Junko Suenaga Shigeyuki Kaino Seiji Maehara Shinichiro Maehara Yoshihiko Sakaida Isao Nakamura Kazuyuki Publishers : International Institute of Anticancer Research
山口医学 Volume 63 Issue 4 pp. 301 - 303
published_at 2014-11-01
Publishers : 山口大学医学会
山口医学 Volume 63 Issue 3 pp. 235 - 236
published_at 2014-08-01
Publishers : 山口大学医学会
山口医学 Volume 63 Issue 3 pp. 201 - 205
published_at 2014-08-01
Creators : Fukuda Yoshiharu Publishers : 山口大学医学会
Molecular Genetics and Metabolism Reports Volume 1 Issue 1 pp. 249 - 253
published_at 2014
Creators : Suzuki Akira Nagasaka Hironori Ochi Yasuhiro Kobayashi Kazuhiro Nakamura Hiroshi Nakatani Daisaku Yamaguchi Satoshi Yamaki Shinobu Wada Atsushi Shirata Yoshihisa Hui Shu-Ping Toda Tatsushi Kuroda Hiroshi Chiba Hitoshi Hirano Kenichi Publishers : Elsevier
Journal of cardiology cases Volume 9 Issue 6 pp. 239 - 242
published_at 2014-06
Creators : Sugiyama Eitaro Takenaka Takashi Kato Mizuki Minoshima Akiho Muto Harutatsu Noriyasu Kazuyuki Fujita Masaaki Sato Minoru Betsuyaku Tetsuo Inoue Hitoki Okamoto Hiroshi Kunishige Hideyuki Ishibashi Yoshimitsu Tsukamoto Eriko Nakamura Hiroshi Hasebe Naoyuki Publishers : Elsevier Ireland Ltd
Case Reports in Pathology Volume 2014 pp. 506072 -
published_at 2014
Creators : Kuno Toshiki Nakamura Hiroshi Endo Yutaka Saito Kohei Yamazaki Hiroyuki Motoda Hiroyuki Numasawa Yohei Shimizu Kazuhiko Takahashi Toshiyuki Publishers : Hindawi Publishing Corporation
Social Science and Medicine Volume 104 pp. 201 - 209
published_at 2014-03
Creators : Hiyoshi Ayako Fukuda Yoshiharu Shipley Martin John Brunner Eric J. Publishers : Elsevier Science
Internal Medicine Volume 53 Issue 3 pp. 227 - 232
published_at 2014
Creators : Oda Shinsuke Fujii Yuichi Takemoto Hiroaki Nomura Shuichi Nakayama Hirofumi Toyota Yasushi Nakamura Hiroshi Teragawa Hiroki Publishers : 日本内科学会
Publishers : Yamaguchi University School of Medicine
山口医学 Volume 63 Issue 1 pp. 75 - 77
published_at 2014-02-01
Publishers : 山口大学医学会
山口医学 Volume 63 Issue 1 pp. 71 - 72
published_at 2014-02-01
Publishers : 山口大学医学会
山口医学 Volume 62 Issue 4 pp. 269 - 271
published_at 2013-11-01
Publishers : 山口大学医学会
山口医学 Volume 62 Issue 4 pp. 265 - 268
published_at 2011-11-01
Publishers : 山口大学医学会
山口医学 Volume 62 Issue 4 pp. 241 - 246
published_at 2013-11-01
Creators : Noguchi Norio Hanazono Tadasuke Mori Kenji Okita Kousuke Sakaida Isao Publishers : 山口大学医学会
Journal of Epidemiology and Community Health Volume 67 Issue 11 pp. 960 - 965
published_at 2013
Creators : Hiyoshi Ayako Fukuda Yoshiharu Shipley Martin J Brunner Eric J Publishers : British Medical Association
Clinical Imaging Volume 37 Issue 5 pp. 962 - 964
published_at 2013-09
Creators : Fujita Takeshi Tanabe Masahiro Iida Etsushi Okimoto Tomoaki Matsunaga Naofumi Publishers : Elsevier Science Pub
山口医学 Volume 62 Issue 3 pp. 183 - 185
published_at 2013-08-01
Publishers : 山口大学医学会
山口医学 Volume 62 Issue 3 pp. 177 - 178
published_at 2013-08-01
Publishers : 山口大学医学会
Clinical & experimental neuroimmunology Volume 4 Issue 1 pp. 92 - 103
published_at 2013-06
Creators : Sano Yasuteru Kashiwamura Yoko Abe Masaaki Dieu Le-Ha Huwyler Jörg Shimizu Fumitaka Haruki Hiroyo Maeda Toshihiko Saito Kazuyuki Tasaki Ayako Kanda Takashi Publishers : Japanese Society for Neuroimmunology | Wiley-Blackwell
Journal of the National Institute of Public Health Volume 61 Issue 6 pp. 590 - 597
published_at 2012-12
Creators : Fukuda Yoshiharu Imai Hirohisa Publishers : 国立保健医療科学院
Journal of the National Institute of Public Health Volume 61 Issue 6 pp. 584 - 589
published_at 2012-12
Creators : Imai Hirohisa Nakao Hiroyuki Fukuda Yoshiharu Publishers : 国立保健医療科学院
Social science & medicine Volume 87 pp. 84 - 92
published_at 2013-06
Creators : Hiyoshi Ayako Fukuda Yoshiharu Shipley Martin J. Bartley Mel Brunner Eric J. Publishers : Pergamon | Elsevier Science
Journal of neurology, neurosurgery and psychiatry Volume 84 Issue 7 pp. 756 - 765
published_at 2013-07
Creators : Saito Kazuyuki Shimizu Fumitaka Koga Michiaki Sano Yasuteru Tasaki Ayako Abe Masaaki Haruki Hiroyo Maeda Toshihiko Suzuki Seiko Kusunoki Susumu Mizusawa Hidehiro Kanda Takashi Publishers : British Medical Association
Annals of thoracic surgery Volume 95 Issue 4 pp. 1458 - 1458
published_at 2013-04
Creators : Murakami Masanori Kurazumi Hiroshi Suzuki Ryo Takahashi Masaya Mikamo Akihito Hamano Kimikazu
山口医学 Volume 62 Issue 2 pp. 129 - 130
published_at 2013-05-01
Publishers : 山口大学医学会
山口医学 Volume 62 Issue 2 pp. 125 - 127
published_at 2013-05-01
Publishers : 山口大学医学会
Respiration & circulation Volume 61 Issue 1 pp. 11 - 18
published_at 2013-01
Creators : 田口 昭彦 谷澤 幸生 Publishers : 医学書院
山口医学 Volume 62 Issue 1 pp. 55 - 59
published_at 2013-02-01
Creators : Kawano Michitaka Shirai Yasuyuki Matsunaga Kazuhito Shirasawa Tomohiro Matsunaga Takaharu Yokoyama Yuuichirou Nohara Hiroaki Kondou Satoshi Shingai Yasushi Saitou Mitsuru Publishers : 山口大学医学会
山口医学 Volume 62 Issue 1 pp. 49 - 53
published_at 2013-02-01
Creators : Hanazono Tadasuke Noguchi Norio Mori Kenji Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 61 Issue 1-2 pp. 17 - 22
published_at 2012-05-01
Creators : Yujiri Toshiaki Publishers : 山口大学医学会
山口医学 Volume 61 Issue 1-2 pp. 11 - 16
published_at 2012-05-01
Creators : Hirose Haruji Publishers : 山口大学医学会
山口医学 Volume 61 Issue 3 pp. 121 - 123
published_at 2012-08-01
Publishers : 山口大学医学会
山口医学 Volume 61 Issue 4 pp. 151 - 155
published_at 2012-11-01
Creators : Kugimiya Naruji Kobayashi Seiki Shigeta Masatoshi Ueki Kouichi Enoki Tadahiko Hamano Kimikazu Publishers : 山口大学医学会
山口医学 Volume 61 Issue 4 pp. 147 - 150
published_at 2012-11-01
Creators : Harima Satoko Hashimoto Shinichi Matsunaga Takaharu Tanabe Ryo Okamoto Takeshi Nishikawa Jun Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 61 Issue 4 pp. 135 - 140
published_at 2012-11-01
Creators : Uchiyama Tetsuji Furuya Tomoko Nakajima Masao Adachi Atsushi Uchisako Hiroyuki Sasaki Kohsuke Publishers : 山口大学医学会
山口医学 Volume 61 Issue 3 pp. 93 - 98
published_at 2012-08-01
Creators : Asada Hiromi Tamura Hiroshi Tanabe Manabu Lee Lifa Kizuka Fumie Tamura Isao Maekawa Ryo Taketani Toshiaki Yamagata Yoshiaki Sugino Norihiro Publishers : 山口大学医学会
Publishers : Yamaguchi University School of Medicine
An official journal of the Japan Primary Care Association Volume 35 Issue 3 pp. 204 - 208
published_at 2012
Creators : Nakashima Yutaka Fukuda Yoshiharu Harada Masanori Nakamori Yoshiaki Publishers : 日本プライマリ・ケア連合学会
Environmental health and preventive medicine Volume 17 Issue 4 pp. 299 - 306
published_at 2012-07
Creators : Fukuda Yoshiharu Hiyoshi Ayako Publishers : Japanese Society for Hygiene | 日本衛生学会
Bioscience trends Volume 6 Issue 4 pp. 176 - 182
published_at 2012
Creators : Fukuda Yoshiharu Hiyoshi Ayako Publishers : International Research and Cooperation Association for Bio & Socio-Sciences Advancement
医療と社会 Volume 22 Issue 1 pp. 31 - 39
published_at 2012
Creators : Fukuda Yoshiharu Publishers : 医療科学研究所
Investigative ophthalmology & visual science : journal of clinical and basic research
published_at 2012-05-10
Creators : Zhou Hongyan Kimura Kazuhiro Orita Tomoko Nishida Teruo Sonoda Koh-Hei Publishers : C.V. Mosby
Ulcer research Volume 38 Issue 2 pp. iii - X
published_at 2011-09-20
Creators : 荒川 哲男 竹本 忠良 小林 絢三 桑山 肇 渡辺 俊雄 Publishers : 日本潰瘍学会事務局
日本医療薬学会年会講演要旨集 Volume 21 pp. 259 - 259
published_at 2011-09-09
Creators : 廣實 清司 内田 豊 古川 裕之 笠井 直樹 水津 賢治 杉山 美由紀 Publishers : 日本医療薬学会年会組織委員会
Journal of gastroenterology
published_at 2012-04-05
Creators : Terai Shuji Tanimoto Haruko Maeda Masaki Zaitsu Junichi Hisanaga Takuro Iwamoto Takuya Fujisawa Koichi Mizunaga Yuko Matsumoto Toshihiko Urata Yohei Marumoto Yoshio Hidaka Isao Ishikawa Tsuyoshi Yokoyama Yuichiro Aoyama Koji Tsuchiya Masako Takami Taro Omori Kaoru Yamamoto Naoki Segawa Makoto Uchida Koichi Yamasaki Takahiro Okita Kiwamu Sakaida Isao Publishers : Springer international | Springer-Verlag
日本公衆衛生雑誌 Volume 58 Issue 11 pp. 935 - 947
published_at 2011-11-15
Creators : Shibui Yu Murayama Hiroshi Kawashima Takako Kano Noriko Toratani Akiko Tachibana Reiko Shibuta Keiko Fukuda Yoshiharu Murashima Sachiyo Publishers : 日本公衆衛生学会
Japanese journal of ophthalmology Volume 56 Issue 1 pp. 104 - 106
published_at 2012-01
Creators : Kondo Yukiko Fukuda Ken Suzuki Katsuyoshi Nishida Teruo Publishers : Department of Ophthalmology School of Medicine University of Tokyo | Japanese Ophthalmological Society
日本細菌学雑誌 Volume 67 Issue 1 pp. 70 - 70
published_at 2012-02-25
Creators : 赤田 純子 中村 和行 倉園 久生 平山 壽哉 梅田 昭子 Nakazawa Teruko 平本 成実 則常 浩太 北川 孝雄 張 秀蓮 藏滿 保宏 奥田 真珠美 福田 能啓 杉山 敏郎 内田 智久 Publishers : 日本細菌学雑誌会
山口医学 Volume 60 Issue 6 pp. 281 - 281
published_at 2011-12-31
Publishers : 山口大学医学会
山口医学 Volume 60 Issue 6 pp. 265 - 279
published_at 2011-12-31
Publishers : 山口大学医学会
山口医学 Volume 60 Issue 6 pp. 249 - 254
published_at 2011-12-31
Creators : Nishimura Junichi Yanai Hideo Furuya Takumi Murakami Tomoyuki Hoashi Seiji Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 60 Issue 6 pp. 243 - 248
published_at 2011-12-31
Creators : Harima Hirofumi Sen-yo Manabu Kaino Seiji Suenaga Shigeyuki Uekitani Toshiyuki Yoshida Kanako Harano Megumi Suzuki Nobuaki Oka Masaaki Sakaida Isao Publishers : 山口大学医学会
山口医学 Volume 60 Issue 5 pp. 215 - 217
published_at 2011-10-31
Publishers : 山口大学医学会
山口医学 Volume 60 Issue 5 pp. 209 - 213
published_at 2011-10-31
Publishers : 山口大学医学会
山口医学 Volume 60 Issue 5 pp. 207 - 207
published_at 2011-10-31
Publishers : 山口大学医学会
山口医学 Volume 60 Issue 5 pp. 199 - 205
published_at 2011-10-31
Publishers : 山口大学医学会
山口医学 Volume 60 Issue 5 pp. 197 - 198
published_at 2011-10-31
Publishers : 山口大学医学会
山口医学 Volume 60 Issue 5 pp. 193 - 195
published_at 2011-10-31
Publishers : 山口大学医学会
山口医学 Volume 60 Issue 5 pp. 191 - 191
published_at 2011-10-31
Publishers : 山口大学医学会
山口医学 Volume 60 Issue 5 pp. 185 - 190
published_at 2011-10-31
Creators : Shibata Hiroaki Hashimoto Shin-ichi Matsunaga Takaharu Tanabe Ryo Shimizu Kensaku Matsukuma Satoshi Hazama Shoichi Oka Masaaki Sakaida Isao Publishers : 山口大学医学会