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Development of new therapy in fulminant hepatitis from glucagon-insulin therapy to bone marrow cell transplantation

The bulletin of the Yamaguchi Medical School Volume 52 Issue 3-4 Page 25-31
published_at 2005-12
A020052000301
[fulltext] 649 KB
Title
Development of new therapy in fulminant hepatitis from glucagon-insulin therapy to bone marrow cell transplantation
Abstract
Application of cell therapy using stem cell into intractable diseases has been noted as the medicine in the next generation taking the place of organ transplantation. Bone marrow cells have been focused as a candidate of the source of this therapy. Liver failure is a terminal state of all advanced liver diseases and thousands of patients are dying of decompensated liver cirrhosis in every year in Japan. Liver transplantation must be the strongest weapon to relieve those patients. However, particularly in Japan, liver transplantation has not been popularized. In this sense, we thought of autologous bone marrow cells transplantation for decompensated liver cirrhosis. Basic studies using animal model revealed that transplanted bone marrow cells into syngenic mouse suffering from liver cirrhosis migrated into the damaged liver and transdifferentiated to the hepatocytes. Based upon the animal studies, clinical trial of this new cell therapy supported by the Ministry of Health, Labor and Welfare is ongoing. It is early to estimate this therapy. However, free from liver failure has been observed in some cases.
Creators Okita Kiwamu
Creators Sakaida Isao
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Terai Shuji
Creators Yamamoto Naoki
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Omori Kaoru
Creators Ishikawa Tsuyoshi
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Aoyama Kouji
Creators Shinoda Koh
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Hamamoto Yoshihiko
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Source Identifiers [PISSN] 0513-1812 [EISSN] 2436-696X
Creator Keywords
fulminant hepatitis fulminant hepatic failure glucagon-insulin therapy bone marrow cell transplantation stem cell
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2005-12
File Version Version of Record
Access Rights open access
Funding Refs
Japan Society for the Promotion of Science
Award REGULATION OF HEPATOCYTE GROWTH 10470136
Funding Refs
Japan Society for the Promotion of Science
Award hypoxiaによる肝星細胞活性化機序の解明 12670490
Funding Refs
Japan Society for the Promotion of Science
Award The analysis for proliferation and differentiation of hepatic stem cells 13470121
Funding Refs
Japan Society for the Promotion of Science
Award 骨髄血投与による肝臓リモデリングの基礎的検討 13770262
Funding Refs
Japan Society for the Promotion of Science
Award 骨髄細胞から肝細胞への分化を制御する遺伝子群の同定プロジェクト 15790348
Funding Refs
Japan Society for the Promotion of Science
Award Analysis of the serum factor which promotes the repopulation and differentiation of the bone marrow cell into hepatocyte. 16390211
Funding Refs
Japan Society for the Promotion of Science
Award The development of cell therapy for liver fibrolysis and prevention of carcinogenesis using bone marrow cell transplantaion 16590597
Schools 医学部