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Utility of real-time tissue elastography in the sequential evaluation of liver fibrosis in patients with chronic hepatitis C

The bulletin of the Yamaguchi Medical School Volume 66 Issue 1-2 Page 29-35
published_at 2019
A050066000104.pdf
[fulltext] 830 KB
Title
Utility of real-time tissue elastography in the sequential evaluation of liver fibrosis in patients with chronic hepatitis C
Creators Hanazono Tadasuke
Creators Hidaka Isao
Creators Maeda Masaki
Creators Saeki Issei
Creators Iwamoto Takuya
Creators Ishikawa Tsuyoshi
Creators Takami Taro
Creators Yamasaki Takahiro
Creators Sakaida Isao
Source Identifiers
Creator Keywords
real-time tissue elastography liver fibrosis HCV interferon
Liver fibrosis is related to hepatocarcinogenesis in patients with chronic hepatitis C. Real-time tissue elastography (RTE) is a useful tool for evaluating liver fibrosis. In this study, we investigated the clinical utility of RTE to sequentially evaluate liver fibrosis in 30 patients with chronic hepatitis C undergoing interferon-based therapy. We compared the change in liver fibrosis index measured by RTE before and after treatment with the change in aminotransferase-to-platelet ratio index. In addition, we compared them across patients who were divided into two groups based on pretreatment alanine transaminase (ALT) level. Liver fibrosis index at pretreatment and at achievement of sustained virological response were 2.27 and 1.94 (p=0.0003), respectively. The aminotransferase-to-platelet ratio index also decreased significantly from 0.78 to 0.40 (p<0.0001). The liver fibrosis index showed significant improvement in both the ALT elevated group (ALT≥31 IU/L) (p=0.0265) and the persistently normal ALT group (ALT<30 IU/L) (p=0.0234). By contrast, the aminotransferase-toplatelet ratio index did not show significant improvement in the persistently normal ALT group (p=0.2813). We consider RTE as one of the non-invasive modalities, which can replace liver biopsy for sequential evaluation of liver fibrosis in patients with chronic hepatitis C.
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2019
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 大学院医学系研究科(医学) 医学部附属病院