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A case of chronic hepatitis c with charcot-marie-tooth disease successfully treated with interferon beta and rivabirin combination therapy

山口医学 Volume 64 Issue 1 Page 53-57
published_at 2015-02-01
B030064000108.pdf
[fulltext] 2.22 MB
Title
Interferonβ+ribavirin併用療法によりsustained virological responseが得られたCharcot-Marie-Tooth病合併C型慢性肝炎の一例
A case of chronic hepatitis c with charcot-marie-tooth disease successfully treated with interferon beta and rivabirin combination therapy
Abstract
A 36-year-old man diagnosed with Charcot-Marie-Tooth(CMT)disease type 1B was treated in the department of neurology of this hospital. Due to a liver injury(AST 237IU/ml, ALT 496IU/ml)which occurred in November 200X, he was introduced to our department. As a result of scrutiny, we diagnosed him with chronic hepatitis C genotype 2a(HCV-RNA 5.4logIU/ml).He will be admitted to the hospital for Interferon(IFN)therapy in April next year. Although the mechanism is unknown, there are a few reports of peripheral neuropathy related to IFN therapy. Therefore, IFN therapy is generally unfavorable for patients with neuromuscular disorders. There are several IFN preparations used in Japan. IFN alfa associated peripheral neuropathy appears less than 0.1-5% of the time. While there is no report of peripheral neuropathy related to IFN beta, we performed IFN beta and Rivabirin combination therapy with a severe follow-up by a neurologist. We could accomplish treatment without the exacerbation of neurologic symptoms. He achieved sustained viral response. When IFN therapy was provided for chronic hepatitis B or chronic hepatitis C complicated with peripheral neuropathy, there is some possibility of performing antiviral therapy safely by using IFN beta.
Creators Matsuura Keiji
Creators Hidaka Isao
Creators Hanazono Tadasuke
Creators Saeki Issei
Creators Iwamoto Takuya
Creators Ishikawa Tsuyoshi
Creators Takami Taro
Creators Kawai Motoharu
Creators Terai Shuji
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Takashi Takashi
Creators Sakaida Isao
Source Identifiers [PISSN] 0513-1731 [NCID] AN00243156
Creator Keywords
C型慢性肝炎 インターフェロン Charcot-Marie-Tooth病
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 2015-02-01
File Version Version of Record
Access Rights open access
Schools 医学部附属病院 大学院医学系研究科(医学)