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resource typejournal article school大学院医学系研究科(医学)
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Background The lipid-lowering therapy by statins may stabilize and reduce coronary plaques. We compare the effect of strong or moderate statins on the coronary plaque characteristics by using 64-slice multidetector computed tomography (MDCT). Methods and Results We analyzed 13 subjects with non-calcified coronary plaques(NCP)as determined by MDCT. Pitavastatin(PTV:2mg/day)or pravastatin(PRA:10mg/day)were randomly administered. MDCT were performed at 0, 6 and 12 months after lipid-lowering therapy. In PTV group(n=6),CT density of NCP increased by 35.6 ± 28.8 HU after 6 months(p=0.037)and by 30.6 ± 29.8 HU after 12 months(NS).NCP area was decreased by 35.9 ± 15.2 % after 6 months and by 41.0 ± 16.5 % after 12 months(both P=0.001).In PRA group(n=7),CT density of NCP did not significantly increased after 6 months(NS)and after 12 months(NS).NCP area was not significantly decreased at 6 months(NS),but decreased by 23.1 ± 16.7 % at 12 months(P=0.001). Conclusions Serial CT angiography revealed that the regression of NCP occurs rapidly by strong lipid lowering therapy compared to the moderate statin therapy.
Creators : Nao Tomoko | Miura Toshiro | Yoshimura Masayuki | Fujimura Tatsuhiro | Nakashima Yoshiteru | Okada Munemasa | Matsunaga Naofumi | Yano Masafumi Publishers : 山口大学医学会 Date Issued : 2017-05-01
Creators : Shindo Yoshitaro | Hazama Shoichi | Inoue Yuka | Kandkiyo Shinsuke | Watanabe Yusaku | Yoshimura Kiyoshi | Yosino Shigefumi | Oka Masaaki Publishers : 日本外科系連合学会 Date Issued : 2013
Creators : Tamesa Takao | Sakamoto Kazuhiko | Kuwahara Taichi | Hashimoto Noriaki | Tokumitsu Yukio | Shindo Yoshitaro | Iida Michihisa | Tokuhisa Yoshihiro | Maeda Yoshinari | Suzuki Nobuaki | Yoshimura Kiyoshi | Ueno Tomio | Yoshino Shigefumi | Hazama Shoichi | Oka Masaaki Publishers : 癌と化学療法社 Date Issued : 2013-11
Creators : Yamashita Osamu | Yoshimura Koichi | Nagasawa Ayako | Ueda Koshiro | Morikage Noriyasu | Ikeda Yasuhiro | Hamano Kimikazu Publishers : Public Library of Science Date Issued : 2013
A phase I clinical trial of vaccination with KIF20A-derived peptide in combination with gemcitabine for patients with advanced pancreatic cancer
Journal of Immunotherapy : official journal of the Society for Biological Therapy Volume 37 Issue 1
Creators : Suzuki Nobuaki | Hazama Shoichi | Ueno Tomio | Matsui Hiroto | Shindo Yoshitaro | Iida Michihisa | Yoshimura Kiyoshi | Yoshino Shigefumi | Takeda Kazuyoshi | Oka Masaaki Publishers : Raven Press | Lippincott Williams & Wilkins Date Issued : 2014-01
Creators : Sato Masafumi | Mikamo Akihito | Kurazumi Hiroshi | Suzuki Ryo | Murakami Masanori | Kobayashi Toshiro | Yoshimura Koichi | Hamano Kimikazu Publishers : Biomed Central Date Issued : 2013-02-28
Creators : Yoshimura Koichi | Ikeda Yasuhiro | Aoki Hiroki Publishers : Elsevier | Elsevier Science Ireland Date Issued : 2011-10
Recent advances in pharmacotherapy development for abdominal aortic aneurysm
International Journal of Vascular Medicine Volume 2012
Creators : Yoshimura Koichi | Aoki Hiroki Publishers : Hindawi Publishing Corporation Date Issued : 2012-08-21
Creators : 藤田 昭子 | 伊達 典子 | 吉村 郁恵 | 藤田 美穂 | 丸山 奈美 | 小川 栄子 | 堤 雅恵 Publishers : へるす出版 Date Issued : 2012-07-15
Inhibition of development of abdominal aortic aneurysm by glycolysis restriction
Arteriosclerosis, thrombosis, and vascular biology Volume 32 Issue 6
Creators : Tsuruda Toshihiro | Hatakeyama Kinta | Nagamachi Shigeki | Sekita Yoko | Sakamoto Sumiharu | Endo George J. | Nishimura Masanori | Matsuyama Masakazu | Yoshimura Koichi | Sato Yuko | Onitsuka Toshio | Imamura Takuroh | Asada Yujiro | Kitamura Kazuo Publishers : American Heart Association Date Issued : 2012-06
Overexpression of the RD RNA binding protein in hepatitis C virus-related hepatocellular carcinoma
Oncology reports : an international journal devoted to fundamental and applied research in oncology Volume 28 Issue 2
Creators : Iida Michihisa | Iizuka Norio | Tsunedomi Ryouichi | Tsutsui Masahiro | Yoshida Shin | Maeda Yoshinari | Tokuhisa Yoshihiro | Sakamoto Kazuhiko | Yoshimura Kiyoshi | Tamesa Takao | Oka Masaaki Publishers : National Hellenic Research Foundation Date Issued : 2012-05-18
Creators : Kaneko Hidehiro | Anzai Toshihisa | Takahashi Toshiyuki | Kohno Takashi | Shimoda Masayuki | Sasaki Aya | Shimizu Hideyuki | Nagai Toshiyuki | Maekawa Yuichiro | Yoshimura Koichi | Aoki Hiroki | Yoshikawa Tsutomu | Okada Yasunori | Yozu Ryohei | Ogawa Satoshi | Fukuda Keiichi Publishers : British Medical Association | Elsevier Science Date Issued : 2011-07-15
Creators : Aoyama Hidekazu | Ikeda Yasuhiro | Miyazaki Yosuke | Yoshimura Koichi | Nishino Shizuka | Yamamoto Takeshi | Yano Masafumi | Inui Makoto | Aoki Hiroki | Matsuzaki Masunori Publishers : British Medical Association | Elsevier Science Date Issued : 2011-01-01
Creators : Kaneko Hidehiro | Anzai Toshihisa | Morisawa Maho | Kohno Takashi | Nagai Toshiyuki | Anzai Atsushi | Takahashi Toshiyuki | Shimoda Masayuki | Sasaki Aya | Maekawa Yuichiro | Yoshimura Koichi | Aoki Hiroki | Tsubota Kazuo | Yoshikawa Tsutomu | Okada Yasunori | Ogawa Satoshi | Fukuda Keiichi Publishers : Elsevier | Elsevier Science Ireland Date Issued : 2011-08
Creators : Maeda Kazunari | Hazama Shoichi | Tokuno Kazuhisa | Kan Shin | Maeda Yoshinari | Watanabe Yusaku | Kamei Ryoji | Shindo Yoshitaro | Maeda Noriko | Yoshimura Kiyoshi | Yoshino Shigefumi | Oka Masaaki Publishers : Potamitis Press Date Issued : 2011-12