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Nobiletin protects hair cells against neomycin-induced vestibular hair cell death

Medical Science & Innovation Volume 71 Issue 1-2

Vestibular hair cells are susceptible to damage from various stimuli such as infections, ischemia, and certain therapeutic drugs, including aminoglycoside antibiotics and the antineoplastic agent cisplatin. In mammals, damage to the vestibular hair cells is permanent. This study aimed to evaluate the protective effects of nobiletin (NOB) against aminoglycoside-induced hair cell death using utricles collected from adult mice. The utricles removed from CBA/N mice were assigned to eight groups according to the dose of NOB and the administration or not of neomycin. Hair cells in the utricles were counted by double labeling with calmodulin and calbindin. NOB inhibited hair cell death in utricles exposed to neomycin. The protective effect of NOB on hair cells in the utricles was also suggested to have resulted from the inhibition of the production and accumulation of 4-hydroxy-2-nonenal, the final product of lipid peroxide aldehyde. NOB suppressed neomycin-induced hair cell death. The principle of hair cell protection from aminoglycoside-induced hair cell death suggests that NOB inhibits reactive oxygen species formation in the utricles exposed to neomycin.

Creators : Masaki Tatsuya | Sugahara Kazuma | Hashimoto Makoto | Yamashita Hiroshi Publishers : Yamaguchi University School of Medicine Date Issued : 2024-06

Apoptosis induced by Ibaraki virus does not affect virus replication and cell death in hamster lung HmLu-1 cells

Journal of Veterinary Medical Science Volume 81 Issue 2

Creators : Tsuruta Yuya | Shibutani Shusaku T. | Watanabe Rie | Iwata Hiroyuki Publishers : 日本獣医学会 Date Issued : 2019

Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice

International journal of molecular sciences Volume 14 Issue 1

A potential therapeutic application of SET/I2PP2A Inhibitor OP449 for Canine T-cell lymphoma

The journal of veterinary medical science Volume 75 Issue 3

Combined effect of molecular-targeted agent Bortezomib and S-1 on oral squamous cell carcinomas

Head and neck cancer Volume 37 Issue 4

Creators : 原田豊子 | 原田耕志 | 上山吉哉 Publishers : 日本頭頸部癌学会 Date Issued : 2011-12-25

Identification of differentially expressed proteins in tumour necrosis factor-alpha-resistant and -sensitive rat hepatoma cells

Anticancer research Volume 31 Issue 6

Creators : Kuramitsu Yasuhiro | Zhang Xiulian | Wang Yufeng | Nakamura Kazuyuki Publishers : Potamitis Press Date Issued : 2011-06

Generation of free radicals during lipid hydroperoxide-triggered apoptosis in PC12h cells

Biochimica et biophysica acta. Lipids and lipid metabolism Volume 1345 Issue 1

Changes in mitochondrial membrane potential during oxidative stress-induced apoptosis in PC12 cells

Journal of neuroscience research Volume 50 Issue 3

Creators : Satoh Takumi | Enokido Yasushi | Aoshima Hitoshi | Uchiyama Yasuo | Hatanaka Hiroshi Publishers : Wiley Date Issued : 1997-11

Modelling and simulation of signal transductions in an apoptosis pathway by using timed Petri nets

Journal of biosciences Volume 32 Issue 1

Creators : Li Chen | Ge Qi-Wei | Nakata Mitsuru | Matsuno Hiroshi | Miyano Satoru Publishers : Springer Date Issued : 2007-01

Biopathways representation and simulation on hybrid functional Petri net

In silico biology Volume 3 Issue 3

Down-regulation of Ras / Akt Signaling and Hippocampal Neuronal Death following Transient Global Ischemia-Reperfusion in Rat brain

The bulletin of the Yamaguchi Medical School Volume 53 Issue 1-2

Interferon-α promotes heat-induced apoptosis in human myeloid leukemia cells

The bulletin of the Yamaguchi Medical School Volume 49 Issue 1-2

Creators : Seguchi Masato Publishers : Yamaguchi University Graduate School of Medicine Date Issued : 2002-06

Tumor-associated ov-serpin, SCC Antigen, is involved in apoptosis

The bulletin of the Yamaguchi Medical School Volume 48 Issue 3-4

Creators : Suminami Yoshinori Publishers : Yamaguchi University Graduate School of Medicine Date Issued : 2001-12