Development of new therapy in fulminant hepatitis from glucagon-insulin therapy to bone marrow cell transplantation
The bulletin of the Yamaguchi Medical School Volume 52 Issue 3-4
Page 25-31
published_at 2005-12
Title
Development of new therapy in fulminant hepatitis from glucagon-insulin therapy to bone marrow cell transplantation
Abstract
Application of cell therapy using stem cell into intractable diseases has been noted as the medicine in the next generation taking the place of organ transplantation. Bone marrow cells have been focused as a candidate of the source of this therapy. Liver failure is a terminal state of all advanced liver diseases and thousands of patients are dying of decompensated liver cirrhosis in every year in Japan. Liver transplantation must be the strongest weapon to relieve those patients. However, particularly in Japan, liver transplantation has not been popularized. In this sense, we thought of autologous bone marrow cells transplantation for decompensated liver cirrhosis. Basic studies using animal model revealed that transplanted bone marrow cells into syngenic mouse suffering from liver cirrhosis migrated into the damaged liver and transdifferentiated to the hepatocytes. Based upon the animal studies, clinical trial of this new cell therapy supported by the Ministry of Health, Labor and Welfare is ongoing. It is early to estimate this therapy. However, free from liver failure has been observed in some cases.
Creators
Okita Kiwamu
Creators
Omori Kaoru
Creators
Aoyama Kouji
Source Identifiers
[PISSN] 0513-1812
[EISSN] 2436-696X
Creator Keywords
fulminant hepatitis
fulminant hepatic failure
glucagon-insulin therapy bone marrow cell transplantation
stem cell
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University School of Medicine
Date Issued
2005-12
File Version
Version of Record
Access Rights
open access
Funding Refs
Japan Society for the Promotion of Science
[crossref_funder]https://doi.org/10.13039/501100001691
Award
REGULATION OF HEPATOCYTE GROWTH
10470136
Funding Refs
Japan Society for the Promotion of Science
[crossref_funder]https://doi.org/10.13039/501100001691
Award
hypoxiaによる肝星細胞活性化機序の解明
12670490
Funding Refs
Japan Society for the Promotion of Science
[crossref_funder]https://doi.org/10.13039/501100001691
Award
The analysis for proliferation and differentiation of hepatic stem cells
13470121
Funding Refs
Japan Society for the Promotion of Science
[crossref_funder]https://doi.org/10.13039/501100001691
Award
骨髄血投与による肝臓リモデリングの基礎的検討
13770262
Funding Refs
Japan Society for the Promotion of Science
[crossref_funder]https://doi.org/10.13039/501100001691
Award
骨髄細胞から肝細胞への分化を制御する遺伝子群の同定プロジェクト
15790348
Funding Refs
Japan Society for the Promotion of Science
[crossref_funder]https://doi.org/10.13039/501100001691
Award
Analysis of the serum factor which promotes the repopulation and differentiation of the bone marrow cell into hepatocyte.
16390211
Funding Refs
Japan Society for the Promotion of Science
[crossref_funder]https://doi.org/10.13039/501100001691
Award
The development of cell therapy for liver fibrolysis and prevention of carcinogenesis using bone marrow cell transplantaion
16590597
Schools
医学部