Expression of an Immunotherapeutic Target Antigen 17-1A for Colorectal Cancer in Multiple Myeloma
The bulletin of the Yamaguchi Medical School Volume 47 Issue 1-2
Page 17-20
published_at 2000-06
Title
Expression of an Immunotherapeutic Target Antigen 17-1A for Colorectal Cancer in Multiple Myeloma
Creators
Hayashi Toshiaki
Creators
Takahashi Tohru
Creators
Adachi Masaaki
Creators
Imai Kohzoh
Source Identifiers
Creator Keywords
antigen 17-1A
colorectal cancer
monoclonal antibody
multiple myeloma
immunotherapy
A colorectal cancer-associated 17-1A antigen is an effective therapeutic target with monoclonal antibody (mAb) for preventing the recurrence of colorectal cancer. We evaluated its expression in myeloma cell lines and bone marrow cells from patients with multiple myeloma or primary macroglobulinemia by indirect immunofluorescence assays. Antigen 17-1A was shown positive in 3 out of 4 cell lines tested and in 8 out of 9 bone marrow cell specimens including 6 multiple myelomas, one IgG-producing chronic lymphoproliferation and 2 primary macroglobulinemias. These data suggest that adminisration of mAb 17-1A may be a new feasible immunotherapy to those indolent, but incurable diseases.
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University Graduate School of Medicine
Date Issued
2000-06
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
医学部