Contents Menu

Suenaga Shigeyuki

Affiliate Master Yamaguchi University

Efficacy of quantitative analysis for differentiating pancreatic solid lesions using contrast-enhanced endoscopic ultrasonography

The bulletin of the Yamaguchi Medical School Volume 68 Issue 1-2 Page 11-20
published_at 2021
A050068000103.pdf
[fulltext] 2.29 MB
Title
Efficacy of quantitative analysis for differentiating pancreatic solid lesions using contrast-enhanced endoscopic ultrasonography
Abstract
Aim: To evaluate the efficacy of quantitative analysis for differentiating pancreatic ductal adenocarcinoma (PDAC) and inflammatory pancreatic masses (IPM) using time intensity curve (TIC) analysis based on contrast-enhanced endoscopic ultrasonography (CE-EUS). Methods: We reviewed 89 patients who had undergone CE-EUS for pancreatic solid lesions at our department between August 2012 and January 2016. CE-EUS images were recorded for 2 minutes after injection of the contrast agent. The diagnostic abilities of the enhanced patterns and TIC analysis were assessed. Results: The enhanced patterns of PDAC were mainly hypovascular and heterogeneous (66/77), while IPM were mainly isovascular and homogeneous (6/12). In PDAC, sensitivity was 77.9%, specificity 83.3%, and accuracy was 78.7%. In TIC analysis, the intensity reduction rate was significantly different at 10 and 30 seconds after peak intensity. After creating a cutoff value (49%) based on the receiver operating characteristic curve for the intensity reduction rate after 30 seconds, diagnosing PDAC with TIC analysis had a sensitivity of 67.5%, specificity of 100%, and accuracy of 71.9%. Combining enhanced pattern analysis with TIC analysis had a sensitivity of 90.9%, pecificity of 83.3%, and accuracy of 89.9%. Conclusion: Combining TIC analysis with CE-EUS improved diagnostic accuracy when differentiating between PDAC and IPM.
Creators Yasuda Mayumi
Creators Kaino Seiji
Creators Tsuyama Takanori
Creators Fujimoto Yuko
Creators Amano Shogo
Creators Harima Hirofumi
Creators Suenaga Shigeyuki
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Sakaida Isao
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Source Identifiers [PISSN] 0513-1812 [NCID] AA00594272
Creator Keywords
contrast-enhanced endoscopic ultrasonography pancreatic ductal adenocarcinoma inflammatory pancreatic mass time intensity curve analysis quantitative analysis
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2021
File Version Version of Record
Access Rights open access
Schools 大学院医学系研究科(医学)