Development of new therapy in fulminant hepatitis from glucagon-insulin therapy to bone marrow cell transplantation

Application of cell therapy using stem cell into intractable diseases has been noted as the medicine in the next generation taking the place of organ transplantation. Bone marrow cells have been focused as a candidate of the source of this therapy. Liver failure is a terminal state of all advanced liver diseases and thousands of patients are dying of decompensated liver cirrhosis in every year in Japan. Liver transplantation must be the strongest weapon to relieve those patients. However, particularly in Japan, liver transplantation has not been popularized. In this sense, we thought of autologous bone marrow cells transplantation for decompensated liver cirrhosis. Basic studies using animal model revealed that transplanted bone marrow cells into syngenic mouse suffering from liver cirrhosis migrated into the damaged liver and transdifferentiated to the hepatocytes. Based upon the animal studies, clinical trial of this new cell therapy supported by the Ministry of Health, Labor and Welfare is ongoing. It is early to estimate this therapy. However, free from liver failure has been observed in some cases.

Creators Okita Kiwamu

Creators Sakaida Isao

Creators Terai Shuji

Creators Yamamoto Naoki

Creators Omori Kaoru

Creators Ishikawa Tsuyoshi

Creators Aoyama Kouji

Creators Shinoda Koh

Creators Hamamoto Yoshihiko

Award REGULATION OF HEPATOCYTE GROWTH 10470136

Award hypoxiaによる肝星細胞活性化機序の解明 12670490

Award The analysis for proliferation and differentiation of hepatic stem cells 13470121

Award 骨髄血投与による肝臓リモデリングの基礎的検討 13770262

Award 骨髄細胞から肝細胞への分化を制御する遺伝子群の同定プロジェクト 15790348

Award Analysis of the serum factor which promotes the repopulation and differentiation of the bone marrow cell into hepatocyte. 16390211

Award The development of cell therapy for liver fibrolysis and prevention of carcinogenesis using bone marrow cell transplantaion 16590597