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The Effect of Hyperkalemic Cardioplegia Containing Nitroglycerin or Diltiazem Hydrochloride on Hypertrophied Myocardial Protection.

The bulletin of the Yamaguchi Medical School Volume 43 Issue 3-4 Page 107-115
published_at 1996-12
A020043000311.pdf
[fulltext] 699 KB
Title
The Effect of Hyperkalemic Cardioplegia Containing Nitroglycerin or Diltiazem Hydrochloride on Hypertrophied Myocardial Protection.
Creators Sasaki Jyoji
Source Identifiers
Creator Keywords
Hypertrophied myocardium Myocardial protection Nitroglycerin Diltiazem hydrochloride
A hypertrophy heart may be more susceptible to ischemia during cardiac operantions and require better myocardial protection than a normal heart. We hypothesized that cardioplegia containing vasodilator may be effective for hypertrophied myocardial protection. This study was designed to test this hypothesis. Ascending Aorta of Japanese white rabbits, weighing about 1kg, was banded (AoB) to induce mycardial hypertrophy. Three to four months later from AoB, the isolated heart was perfused using the Langendorff technique with Krebs-Henseleit bicarbonate buffer solution for 15 min, and then preserved for 2 hours in cardioplegic arrest by infusing an initial bolus of 20 ml of 4℃ crystalloid cardioplegic solution. The hearts were divided three groups. Cardiac arrest was induced with modified Yamaguchi university crystalloid cardioplegic solution in Group A (n = 10), with that containing nitroglycerin (10-4 mol/L) in Group B (n = 6),and with that containing Ca2+ antagonist (diltiazem hydrochloride
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1996-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部