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A Study on Malignant Potency of Human and Experimental Esophageal Caustic Burns with Microphotometry and Analysis of Cell Kinetics

山口医学 Volume 35 Issue 5 Page 283-290
published_at 1986-10
Title
腐食性食道損傷組織の核DNA量および細胞動態よりみた前癌性変化の検討
A Study on Malignant Potency of Human and Experimental Esophageal Caustic Burns with Microphotometry and Analysis of Cell Kinetics
Creators Fukuda Shintaro
Source Identifiers
The nuclear DNA content was measured in the cells from resected specimens of 10 patients with esophageal carcinoma, 2 patients with esophageal caustic burns and 10 patients with normal esophagus to investigate the malignant potency of caustic burned esophagus. In addition to the investigation in clinical cases, nuclear DNA content and labelling index were measured in the cells of experimental esophageal lye burns, experimental esophageal carcinomas and normal esophagus. The results were as follows. Mean and mode values of nuclear DNA content of the caustic burn group showed the higher values than those of normal esophagus and the lower values than those of esophageal carcinomas in humans, rats and rabbits (P<0.05). Though pathological findings showed slight atypism in the caustic burn group, definite diagnosis of the carcinoma or carcinoma in situ was not obtained. Labelling index was measured on the cells of esophageal caustic burn group and normal esophagus group. The mean value of each group showed significant difference. Higher value was obtained in the caustic burn group. The findings indicate that the esophageal caustic burn may have malignant potency.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1986-10
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部