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Effects of Calcium on the Production of Squamous Cell Carcinoma Antigen in Normal Human Keratinocytes

山口医学 Volume 43 Issue 6 Page 419-426
published_at 1994-12
Title
正常ヒトkeratinocyteのSCC抗原産生能に及ぼすカルシウムの影響
Effects of Calcium on the Production of Squamous Cell Carcinoma Antigen in Normal Human Keratinocytes
Creators Tsunaga Nagato
Source Identifiers
Creator Keywords
SCC抗原 karatinocyte カルシウム
Squamous cell carcinoma antigen (SCC antigen) is a member of serine protease inhibitor's family, and appears in the differentiated types of malignant and nonmalignant squamous cells. This study shows the effects of calcium on the production of SCC antigen in normal human keratinocytes. The keratinocytes were treated with calcium with final concentration of 0.15, 0.5, 1.0 and 2.0mM for up to 5 days. mRNA expression and cytoplasmic contents of SCC antigen were significantly increased by 0.5 and 1.0mM calcium, but the release of SCC antigen into the medium rather decreased as the calcium concentrations were increased, showing the different behaviors in the production and release of SCC antigen. The immunohistochemical studies using a specific monoclonal antibody against SCC antigen also demonstrated that the intensity of staining was increased significantly in the calcium treated keratinocytes. These results indicated that calcium would influence the production and release of SCC antigen in keratinocyte, which should be involved in the proliferation and the differentiation of keratinocyte.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1994-12
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部