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Microdeposits of Amyloid in the Aged and their Significance

山口医学 Volume 32 Issue 3 Page 235-246
published_at 1983-06
Title
高齢者における微量アミロイドの沈着とその意義
Microdeposits of Amyloid in the Aged and their Significance
Creators Nagasawa Takaaki
Source Identifiers
The incidence and the organ distribution of amyloid deposits in the aged human were studied. One hundred and ten autopsied cases over seventy years old without systemic amyloidosis were examined retrospectively by polarizing microscopy of Congo red stained sections. In eighty-one cases, amyloid deposits were found in at least one of the examined organs and the overall incidence was 73.6%. Although the incidence of amyloid deposits increased with age, e. g. 65. 3% in 70-74 years old, 77.1% in 75-79, 84.6% in over 80, this phenomenon was not statistically significant. The aorta showed higher incidence (56/110, 50.9%) than other organs, e. g. pancreas (41/110, 37.3%), brain (5/22, 22.7%), seminal vesicle (3/15, 20.0%), lung (5/106, 4.7%), adrenal gland (2/95, 2.1%), kidney (2/108, 1.9%) and the heart (1/106, 0.9%). These deposits were almost always minute except those of seminal vesicle. Different mechanisms of deposition and protein natures of these ”age-related” amyloid from one organ to another have been postulated. These microdeposits of amyloid are considered to be one of the morphological changes as a result of the aging process.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 1983-06
File Version Not Applicable (or Unknown)
Access Rights metadata only access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 医学部