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Comparative Effects of Angiotensin II Type 1 Receptor Blockade with Angiotensin-Converting -Enzyme Inhibitor on Aortic Smooth Muscle Cell Phenotype in Spontaneously Hypertensive Rats

The bulletin of the Yamaguchi Medical School Volume 43 Issue 3-4 Page 117-125
published_at 1996-12
A020043000312.pdf
[fulltext] 1.72 MB
Title
Comparative Effects of Angiotensin II Type 1 Receptor Blockade with Angiotensin-Converting -Enzyme Inhibitor on Aortic Smooth Muscle Cell Phenotype in Spontaneously Hypertensive Rats
Creators Fujii Akihisa
Source Identifiers
Creator Keywords
Angiotensin II type 1 receptor blockade Smooth muscle cell Myosin heavy chain isoform Fibrosis Hypertension
To clarify the effects of renin-angiotensin system inhibition on aortic smooth muscle cell phennotype and fibrosis in spontaneously hypertensive rats (SHR), we treated 14-week -old SHR with a selective angiotensin II type 1 (AT1) receptor blockade, FK-739 (30mg/kg day) or sngiotensin-converting-enzyme (ACE) inhibitor, enalapril (10mg/kg/day) for 6 weeks. Both FK-739 and enalapril caused a significant decrease in blood pressere (p < 0.001) with no difference between the treated groups. Immunoblot showed no significant decrease in the expression of smooth muscle cell myosin heavy chain and nonmuscle myosin heavy chain (NMHC)-A in SHR aorta. In contrast, both FK- 739 and enalapril resulted in s significant decrease in the expression of NMHC-B compared with vehicle (vehicle vs FK-739 treated group
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1996-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部