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Antianxiety Effect of Ehtyl Loflazepate, CM6912, Assessed by Frontal Medline Theta Activity in Man

The bulletin of the Yamaguchi Medical School Volume 32 Issue 1 Page 71-77
published_at 1985-12
A020032000110.pdf
[fulltext] 492 KB
Title
Antianxiety Effect of Ehtyl Loflazepate, CM6912, Assessed by Frontal Medline Theta Activity in Man
Creators Mizuki Yasushi
Creators Hirano Hitoshi
Creators Hamasaki Junko
Creators Ushijima Itsuko
Creators Yamada Michio
Creators Tanaka Masatoshi
Creators Inanaga Kazutoyo
Source Identifiers
Creator Keywords
benzodiazepines diazepam CM6912 antianxiety effect frontal midline theta activity (Fmθ)
The theta activity which appears in the frontal midline area during performance of mental tasks been designated as Fmθ. In the present atudy, the potency of CM6912 as an anixiolytic was investigated using Fmθas compared with diazepam. Sixteen male university students were given placebo, diazepam 5 mg, CM6912 2 mg and 4 mg in a double-blind, crossover design. Scores were made on the state anxiety scale of Spielberger`s State Trait Anxiety Inventory (STAI), EEDs were recorded before and during performance of an arithmetic addition. The test was repeated twice, before and 1 hr after drug administration. Placebo increased Fmθ
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1985-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部