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Stress-Indused Hypothermia Involves Stimulation of Adenosine A1-Receptors in Rats

The bulletin of the Yamaguchi Medical School Volume 32 Issue 1 Page 63-69
published_at 1985-12
A020032000109.pdf
[fulltext] 508 KB
Title
Stress-Indused Hypothermia Involves Stimulation of Adenosine A1-Receptors in Rats
Creators Ushijima Itsuko
Creators Mizuki Yasushi
Creators Hara Takahide
Creators Soeda Koichiro
Creators Kudo Ryoji
Creators Miyoshi Akira
Creators Watanabe Katsumi
Creators Kajimura Naofumi
Creators Yamada Michio
Source Identifiers
Creator Keywords
core temperature adenosine adenosine analogs opiate substances stressed and nonstressed rats
Subcutaneous (s.c.) injection of adenosine produced hyperthermia in non-stressed rats and potentiated hypotermia in stressed rats. The potent adenosine A1-recepter stimulants, N6-cyclohexyl adenosine (CHA) and N6-(L-phenylisopropyl) adenosine (L-PIA) prodused hypothermia even in non-stressed rats, which was markedly potentiated in stressed trats. Futhermore, intracerbral ventricular (I.c.v.) injection of adenosine or adenosine analogues produced potentiation of stress-induced hypotermia relative to that induced with s.c.injection. N6-(D-phenylisoprophyl) adenosine (D-PIA) did not affect core temperature. When rats were treated with adenosine 1 h before atress, and then exposed to stress, the hyperthemia exhibited in the non-stressed state changed to hypothermia in the stressed state. When the rats which were treated with adenosine and then atressed for 1 h were released from stress, the hypothermia observed in the atressed state progressively changed to hyperthemia. Low doses of β-endorphin (I.c.v.) and morphine (s.c.)reversed stress-induced hypothermia which was potentiated by CHA, although high doses of β-endorphin (I.c.v.) and morphine (s.c.) potentiated the stress-induced hypothermia. These results suggest that the effects of adenosine on core temperature in rats are altered depending upon the state of animals. Stress-induced hypothermia may be, at least in part, mediated by endogenous adenosine which seems to selectively activate A1-receptor in the stressed state.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1985-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部