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Ultrastructural Study on the Spleens of 28 Patients with ITP:Platelet Phagocytosis of Cordal Macrophages

The bulletin of the Yamaguchi Medical School Volume 32 Issue 1 Page 1-9
published_at 1985-12
A020032000101.pdf
[fulltext] 3.94 MB
Title
Ultrastructural Study on the Spleens of 28 Patients with ITP:Platelet Phagocytosis of Cordal Macrophages
Creators Ishihara Tokuhiro
Creators Yamashita Yoshimi
Creators Gondo Toshikazu
Creators Yokota Tadaaki
Creators Kamei Toshiaki
Creators Takahashi Mutsuo
Creators Uchino Fumiya
Creators Matsumoto Noboru
Source Identifiers
Creator Keywords
ITP Ultrastructure Spleen Platelet Cordal macrophage
Spleens of 28 patients with idiopatic thrombocytopenic purpura have been observed histologically, immunohistologically and electron microscopically. Spleens of fifteen patients had the foamy cells in the red pulp. Some foamy cells had positive materials for anti-human platelet antibody, using the unlabelled immunoperoxidase method. Electorn microscopically, many platelets in varying stages of intracellular digestion from intact-appearing platelets to myelinlike materials were disclosed in the foamy cells. We suggest that there are two types of the macrophage in the spleen from patients with ITP. One does not reveal foamy cytoplasm, because phagocytized are immediately digested by the lysosomal enzyme within cytoplasm of macrophages. The other has foamy cytoplasm, because phagocytized platelets are incompletely digested and remain as myelinlike materials within cytoplasm of macrophages.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1985-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部