Detection of K-ras Codon 12 Mutation in the Portal Blood during Surgery for Pancreatic Carcinoma

Detection of K-ras Codon 12 Mutation in the Portal Blood during Surgery for Pancreatic Carcinoma

Creators Enoki Tadahiko

Creators Morita Nobuyoshi

Creators Inokuchi Tomohiro

Creators Tsushimi Takahiro

Creators Hayashi Daisuke

Creators Okamura Keiji

Creators Shinagawa Hidetaka

Creators Orita Masahiko

Creators Noshima Shinji

Creators Esato Kensuke

Background and Aim : It is well known that pancreatic adenocarcinomas harber K-ras gene point mutations, which are frequently restricted to codon 12. Thus, the detection of K-ras codon 12 mutations in pancreatic or duodenal juice may did in the diagnosis of pancreatic adenocarcinomas. In the present study, we investigated whether or not portal blood collected during surgery for pancreatic adenocarcinoma contains the K-ras codon 12 mutation. Methods : During radical resection for pancreatic adenocarcinoma, 10ml of portal blood was taken twice

[ISSN]0513-1812

[NCID]AA00594272