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In vivo Techniques for Clinical Studies of Glucose Metabolism

The bulletin of the Yamaguchi Medical School Volume 41 Issue 3-4 Page 155-168
published_at 1994-12
A020041000312.pdf
[fulltext] 1.24 MB
Title
In vivo Techniques for Clinical Studies of Glucose Metabolism
Creators Matsuda Masafumi
Source Identifiers
Creator Keywords
Succinylcholine Catecholamines Abnormal Pseudocholinesterase
The use of radioactive tracers is inevitable for in vivo clinical studies outside Japan. In the field of research in diabetes melitus, glucose metabolism is a major concern and has been studied in humans using a tracer technique. The recent advances in this field and other useful in vivo tschnique. The recent advances in this field and other useful in vivo techniques for study of glcose metabolism are reviewed with comments n their problems. Residual hepatic glucose production represents the endogenous glucose production. Blood flow or water exchanfe in organs has been regarded as one of the important factors for the determination of glucose utilization. Total glucose disposal is expressed as approximated glucose infusion rate plus residual hepatic glucose production. Dual atacer (3-3H-glucose, U-14C-glucose) thechnique with indirect calorimetry is useful to address intracellular glucose metabolism. While a minimal model approach has been used especially for the epidemiological research, its theoretical background and problems are discussed. A novel approach to measure glucose transport in vivo makes it possible to estimate intracellular functional glucose concentration. Although the ethical problem of using small doses of radioactive tracer is very difficult to solve in Japan, comprehension of tracer method is important for the understanding of physiopogical aspects of glucose
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1994-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部