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Immunohistochemical Examination of Meningioma

The bulletin of the Yamaguchi Medical School Volume 37 Issue 3-4 Page 107-111
published_at 1990-12
A020037000307.pdf
[fulltext] 990 KB
Title
Immunohistochemical Examination of Meningioma
Creators Kamiryo Toshifumi
Creators Nishizaki Takafumi
Creators Kajiwara Koji
Creators Ito Haruhide
Creators Orita Tetsuji
Source Identifiers
Creator Keywords
Meningioma Hemangiopericytyoma Immunohistochemistry Epithelial membrane antigen Vimentin
Immunohistochemical characteristics were examined in 76 cases of primary meningioma, 10 cases of recurrent meningioma, 3 cases of hemangiopericytoma and 2 cases of meningeal sarcoma. Six antibodies, those against epithelial membrane antigen, vimentin, cytokeratin, S-100 protein and alpha-1-antitrypsin, and 80-90% for neuron-specific enolase. Cytokeratin was negative in all cases. In recurrent meningioma, positivity rates for viementin were slightly lower in comparsion with promary meningioma. The man staining patterns of epithelial membrance antigen, vimentin, S-100 protein and alpha-1-antitrypsin were diffuse and that of neuron-specific enolase was focal. In hemagiopericytoma and meningeal sarcoma, epithelial membrane antigen and cytokeratin were negative and the other antigens were positive. Positivity for epithelial membrance antigen is thus of some use in distinguishing meningioma from hemagiopericytma or meningeal sarcoma. However vimentin, S-100 protein, neuron-spcific enolase and alpha-1-antitrypsin are not specific.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1990-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部