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Monoclonal Antibody May Recognize Highly Evolutionary Conserved Molecule - An Immunocytochemical Study -

The bulletin of the Yamaguchi Medical School Volume 37 Issue 3-4 Page 89-93
published_at 1990-12
A020037000304.pdf
[fulltext] 912 KB
Title
Monoclonal Antibody May Recognize Highly Evolutionary Conserved Molecule - An Immunocytochemical Study -
Creators Tomonaga Susumu
Creators Fujikura Yoshihisa
Creators Sawada Tomoo
Creators Kuniki Hiromichi
Creators Ito Kazuo
Creators Fukumoto Tetsuo
Source Identifiers
Creator Keywords
Monoclonal antibody Evolutionary conserved antigen Thymocytes Brain Immunocytochemistry
A monoclonal antibody, UB-13 which may react highly evolutionary conserved molecule was established. The antibody was made immunizing mice with homogenized skate brain and then cloning both with rat and skate thymocytes. The reactivity of the antibody was analyzed immunocytochemically using the indirect immunocytochemical method. The UB-13 appeared to be reactive with thymocytes of all species of vertebrates examined, such as fish, frog, turtle, chicken and rat. Cells of the nervous system, some populatons of lymphoid cells are also positive with UB-13 immunostaining. These findings strongly suggest that UB-13 is a unipue monoclonal antibody which recognizes evolutionary conserved molecule.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1990-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部