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A Japanese Family of Hereditary Deficiency of Plasma Thromboplastin Antecedent (Factor ⅩⅠ)

The bulletin of the Yamaguchi Medical School Volume 32 Issue 1 Page 53-56
published_at 1985-12
A020032000107.pdf
[fulltext] 280 KB
Title
A Japanese Family of Hereditary Deficiency of Plasma Thromboplastin Antecedent (Factor ⅩⅠ)
Creators Shinohara kenji
Creators Konishi Yasuko
Creators Azuno Yoichi
Creators Yamada Katsunori
Creators Sasaki Hiroko
Creators Kaneko Toshio
Creators Matsumoto Noboru
Source Identifiers
Creator Keywords
hireditary deficiency of PTA plltelet facter XI-like activity
A Japanese family of hereditary deficiency of plasma thromboplastin antecedent (PTA, factor XI ) was reported. The parents of the propositus were of consanguinous marriage. The levels of plasma factor Xiactivity and anitigen of the homozygotes were less than 1% of normal, and those of heterzygotes were approximately half of normal. The deficiency was transmitted as autosomal recessive trait. The homozygotes had no episodes of troublesome bleedings. The platelets of the propositus contained intrinsic factor XI-like activity as in normal, and the compensatory role of platelet factor XI-like activity for the initiation of the intrinsic pathway of coagulation was suggested.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1985-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部