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Modification of Cerebral Metabolic and Circulatory Response to Nitrous Oxide by Diazepam, Morphine or Hypocapnia in Dogs

The bulletin of the Yamaguchi Medical School Volume 32 Issue 1 Page 43-52
published_at 1985-12
A020032000106.pdf
[fulltext] 705 KB
Title
Modification of Cerebral Metabolic and Circulatory Response to Nitrous Oxide by Diazepam, Morphine or Hypocapnia in Dogs
Creators Tokutsu Yoshimichi
Source Identifiers
Creator Keywords
cerebral metabolism and circulation nitrous oxide diazepam morphine hypocapnia
Modification of cerebral metabolic and circulatory response to nitrous axide by prior administration of diazepam, morphine or induction of hypocapnia was studied in 24 dogs. Nitrous oxide (60 per cent end-tidal) increased cerebral oxygen consumption by 20 per cent and increased cerebral blood flow by 150 per cent initially and then cerebral blood flow declined to 50 per cent adove the control during a 60-min period. Cerebrospinal fluid pressure significantly increased. Diazepam, 0.5 mg/kg, significantly attenuated cerebral metabolic and circulatory stimulation with nitrous oxide for 30 min. Morphine, 1 mg/kg, blocked the cerebral stimulationwith nitrous oxide throughot the period. Increase in cerebrospinal fluid presure was significantly attenuated by both drugs the early period. Indyced hypocapnia transiently but significantly attenuated the increases in cerebral blood flow and cerebrospinal fluid presure with nitrous oxide, while cerebral oxygen consumption was unaffected. These results indicated that cerebral metabolic and circulatory response to nitrous oxide is attenuated or blocked by diazepam, morphine or induced hypocapnia in dogs.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1985-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部