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Pharmacokinetic Study on One Case of High Dose Methotrexate Therapy with Leucovorin Rescue

The bulletin of the Yamaguchi Medical School Volume 35 Issue 1-2 Page 23-29
published_at 1989-06
A020035000104.pdf
[fulltext] 522 KB
Title
Pharmacokinetic Study on One Case of High Dose Methotrexate Therapy with Leucovorin Rescue
Creators Fujita Toshio
Creators Kimoto Hiroo
Creators Koshiro Akira
Creators Yamamoto Norio
Creators Sakatoku Jisaburo
Source Identifiers
Creator Keywords
Methotrexate Pharmacokinetics Cancer chemotherapy High dose methotrexate therapy
High-dose methotrexate therapy in a testicular was studied pharmacokinetically to obtain safe and effective massive methotrexate theraphy. The drug concentration in serum, cerebrospinal fluid and urinary excretion was analyzed according to two-or three-compartment open models. The ratio of exposure to methotrexate in the central vs. the peripheral compartments was calculated to be 1 : 0.14 by a two-compartment open model. A larger amount of methotrexate permeates into the peripheral compartment by passive transport when a high dose, as compared to the usual dose, is used. However, most of the administered mothotrexate is rapidly excreted in urine without any antitumor effects, The urinary excretion showed almost the same pharmacokinetical parameters as obtained from the serum data. The analysis based on a three-compartment open model indicates that the low and sustained serum concentration of methotrexate at the third phase was found to be governed by its release from the third compartment. General consideration about cancer chemotherapy using methotrexate are also discussed.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1989-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部