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The Role of H-Y Antigen in Acute Graft-Versus-Host Responses

The bulletin of the Yamaguchi Medical School Volume 36 Issue 3-4 Page 61-67
published_at 1989-12
A020036000302.pdf
[fulltext] 1.98 MB
Title
The Role of H-Y Antigen in Acute Graft-Versus-Host Responses
Creators Nakatsuji Tadako
Creators Ishihara Tokuhiro
Source Identifiers
Creator Keywords
Acute GVHR H-Y antigen F1 hybrid rat Splenectomy Erythropoiesis
Acute graft-versus-host reactions (GVHRs) to a male-specific (H-Y) antigen have been investigated using a weight assay, a bone marrow assay and a focal periportal proliferation test. Severe acute GVHRs have been marrow assay a focal periportal proliferation test. Severe acute GVHRs have been induced by the injection of female DA rat cells into male (Dax Lewis) F1 hybrid rats. Besides semiallogeneic donor RT1 antigens, host H-Y antigen was concerned strongly with leading to systemic acute GVHRs. Even though there were clinical variations, the acute GVHRs to H-Y antigen were occurred in F1 males, especially by the immunization with DA female spleen cells. When F1 hosts were splenectomized, only mild to moderate acute GVHRs were recognived by the injection of either female or male donor cells. The donor cells obtained from Lewis females that were premmunized with one rat died of typical acute graft-versus-host disease (GVHD). But in the other 3, chromic graft rejection was suggested to add to the GVHRs. Hemolytic anemia and ballooning change of hepatocytes were developed at around 41-63 days after immunization. Acute GVHRs to H-Y antigen led to remarkable erythroid suppression on bone marrow and focal myeloid proliferation in liver.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1989-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部