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Distributions of Catecholamines in the Heart of Mammalian Laboratory Spesies

The bulletin of the Yamaguchi Medical School Volume 31 Issue 1 Page 71-77
published_at 1984-12
A020031000110.pdf
[fulltext] 486 KB
Title
Distributions of Catecholamines in the Heart of Mammalian Laboratory Spesies
Creators Umemoto Seiji
Source Identifiers
Creator Keywords
Catecholamine Heart Tssue High-Performance Liquid Chromatography with Electrochemical Detection
The regional distribution of rats, guinea pigs,rabbits and mice was measure by high-performance liquid chromatography (HPLC) with electrochemical detection (ED). The catecholamines were adsorbed onto alumina and then eluted with 0.5 m hydrochloric acid and assayed by HPLC-ED. The lower limit of detection was about 0.03 -0.05 pmol. The predominant catecholamine was norepinephrine (NE), and dopamine (DA) was second. Epinephrine was not always detected. NE and DA were found in higher concentrations in the atria than in the ventricles. In the mouse NE was found in higher concentrations in the left heart region than in the right heart region. And DA was found in higher concentrations in the left atrium than in the right atrium. In order animals NE and DA were found in higher concentrations in the right heart region than in the left heart region. Thus, in studies of myocaedial catecholamines in addition to catecholamine metabolism it may be useful to consider catecholamine concentrations by heart regions and by species.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1984-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部