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The Cytopathic Effects of Laptospira and Laptonema spp. On Various Tissue Cultured Cells

The bulletin of the Yamaguchi Medical School Volume 36 Issue 1-2 Page 9-16
published_at 1989-06
A020036000102.pdf
[fulltext] 1.73 MB
Title
The Cytopathic Effects of Laptospira and Laptonema spp. On Various Tissue Cultured Cells
Creators Tomita Masaaki
Source Identifiers
Creator Keywords
Leptospira Leptonema Spirochetes Tissue culture Cytopathic effect
The interaction of 18 strains of Leptospira (2 species, 9 serovars) and a strain of Leptonema illini with 6 tissue cultured cell lines (3 epithelial and 3 fibroblastic) during leptospiral replication was investigated. Cytopathic effects ware observed not only on fibrablastic cells but also on epothelial cells infected with leptospires. In addition to most strains of Leptospira interrogans, Leptospira biflexa and L. illini produced cytopathic effects. Thus the cytopathic effect caused by leptospires of L. interrogans servar icterofaemoeehagiae atrain RGA produced cytopathic effect without entering the cells. On the other hand, strain Pyrogenes of L.. Interrogans serovar pyrogenes and strain Akiyami A of serovar autumnalis efficiently attached to and entered pyrogenes and strain Akiyami A of serovar autumnalis efficiently attached to and entered Sf1Ep cells, although they did not produce any cytopathic effect. These results suggest that the cytopathic effects of some pathogenic leptospires are caused by extracellular toxic substances produced by the microorganisms.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1989-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部