Effect of Intravasclar Influsion of Endogenous Pyrogen or Prostaglandin E2 on Neuronal Activity of Rat's Hypothalamus
The bulletin of the Yamaguchi Medical School Volume 36 Issue 1-2
Page 1-8
published_at 1989-06
Title
Effect of Intravasclar Influsion of Endogenous Pyrogen or Prostaglandin E2 on Neuronal Activity of Rat's Hypothalamus
Creators
Sakata Yoshiyuki
Creators
Watanabe Tatsuo
Creators
Morimoto Akio
Creators
Murakami Naotoshi
Source Identifiers
Creator Keywords
Fever
Thermoregulation
Prostaglandin
Endogenous pyrogen
Themoresponsive neuron
We investigated the effects of intracarotid infusion of prostaglandin E2 or intravenous infusion of an endogenous pyrogen on the neuronal activity of the neuronal activity of the preoptic and anterior hypothalamic (PO/AH) region in rats. The present results suggest that thermore sponsive neurons of the PO/AH region respond well to intravascular application of prostaglandin E2 or the endogenous pyrogen, compared with thermally insensive neurons. Intravenous infusion of the endogenous pyrogen attenuated the activities of warm-responsive and facilitated those of cold-responsive neurons. However, the direction of neuronal response induced by intracarotid infusion of prostaglandin E2 could not be categorized based on the thermoresposiveness of the individual neuron.
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University Graduate School of Medicine
Date Issued
1989-06
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
医学部