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Effect of Intravasclar Influsion of Endogenous Pyrogen or Prostaglandin E2 on Neuronal Activity of Rat's Hypothalamus

The bulletin of the Yamaguchi Medical School Volume 36 Issue 1-2 Page 1-8
published_at 1989-06
A020036000101.pdf
[fulltext] 581 KB
Title
Effect of Intravasclar Influsion of Endogenous Pyrogen or Prostaglandin E2 on Neuronal Activity of Rat's Hypothalamus
Creators Sakata Yoshiyuki
Creators Watanabe Tatsuo
Creators Morimoto Akio
Creators Murakami Naotoshi
Source Identifiers
Creator Keywords
Fever Thermoregulation Prostaglandin Endogenous pyrogen Themoresponsive neuron
We investigated the effects of intracarotid infusion of prostaglandin E2 or intravenous infusion of an endogenous pyrogen on the neuronal activity of the neuronal activity of the preoptic and anterior hypothalamic (PO/AH) region in rats. The present results suggest that thermore sponsive neurons of the PO/AH region respond well to intravascular application of prostaglandin E2 or the endogenous pyrogen, compared with thermally insensive neurons. Intravenous infusion of the endogenous pyrogen attenuated the activities of warm-responsive and facilitated those of cold-responsive neurons. However, the direction of neuronal response induced by intracarotid infusion of prostaglandin E2 could not be categorized based on the thermoresposiveness of the individual neuron.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1989-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部