Contents Menu

Change of Thymidine Uptake Rate during Passage through the S Phase : A Study with Retrograde Synchrony Method

The bulletin of the Yamaguchi Medical School Volume 28 Issue 1-2 Page 19-26
published_at 1981-06
A020028000103.pdf
[fulltext] 456 KB
Title
Change of Thymidine Uptake Rate during Passage through the S Phase : A Study with Retrograde Synchrony Method
Creators Okuda Shin-ichiro
Source Identifiers
Creator Keywords
cell cycle S phase thymidine uptake rate retrograde synchrony autoradiogram
Twenty-nine patients with hepatocellular carcinoma (PHC) were given oral administration of 5-Fu (or Futraful) and intermittent intra-arterial infusion with 10-20 mg of Mitomycin C (MMC). Objective responses such as decreased serum α-fetoprotein level, decrease in the liver size, and prolongation of the survival time were found in 15, 14, and 13 out of patients respectively. Subjective symptoms such as weakness, abdominal pain, and loss of appetite were improved in 7 of 29 patients. Of control patients with PHC who received oral administration of 5-Fu (or Futraful) alone, or intra-venous injection of 4 mg of MMC twice a week, the objective responses were observed in one of 13 patients. This indicates significant therapeutic effect of intra-arterial infusion of MMC on patients with PHC. Patients with severe liver dysfunction, decreased number of peripheral lymphocytes, or high level of serum alkaline phosphatase were unsuitable for this infusion. A significant decrease of serum hemoglobin level was observed as a side effect of intra-arterial infusion of MMC.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1981-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部