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Identification of Abnormal Hemoglobin IX. HbA2 Yokoshima δ25(B7)Gly→Asp Found in Homozygous State in Two Japanese Families

The bulletin of the Yamaguchi Medical School Volume 33 Issue 1 Page 63-66
published_at 1986-12
A020033000109.pdf
[fulltext] 462 KB
Title
Identification of Abnormal Hemoglobin IX. HbA2 Yokoshima δ25(B7)Gly→Asp Found in Homozygous State in Two Japanese Families
Creators Fujisawa Keiko
Creators Nakashima Mayumi
Creators Sanada Chizuko
Creators Ami Miyoko
Creators Arai Yasuko
Creators Ohba Yuzo
Creators Miyaji Takaoki
Source Identifiers
Creator Keywords
Abnormal hemoglobin Hemoglobin A2
A variant of HbA2 was found in two patients during a random survey by isoelectric focusing. Chemical characterization of the zbnormal δ chain was facilitated by reverse phase high performance liquid chromatography and automated gas phase amino acid sequencing. The same amino acid aubstitution, from glycine to aspartic acid at position 25 (B7) of the δchain, was demonstrated for both cases. This is the second example of identification of δchain anomaly and includes the second and third examples of homozygosity for an abnormal hemoglobin among Japanese.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1986-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部