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Effects of Lidocaine on Cerebral Energy State and Glycolytic Metabolism in the Rat

The bulletin of the Yamaguchi Medical School Volume 27 Issue 3-4 Page 99-106
published_at 1980-12
A020027000303.pdf
[fulltext] 512 KB
Title
Effects of Lidocaine on Cerebral Energy State and Glycolytic Metabolism in the Rat
Creators Oshibuchi Takao
Source Identifiers
Creator Keywords
lidocaine seizure carebral metabolism electroencephalography
Contractile responses of rabbit aortic strips to transmural stimulation and to exogenously applied norepinephrine (NE), potassium chloride (KCl), and histamine were studied in the presence of lidocaine or its metabolite, glycinexylidide (GX). Lidocine, 10^-4 and 5×10^-4M, attenuated the contractile response to transmural stimulation. GX, 2×10^-5 to 5×10^-4M, potentiated the response to transmural stimulation. The suppression induced by lidocaine was not reversed by excess calcium, 2.2 and 4.4 mM, but was partially reversed by cocaine, 3×10^-6M. Lidocaine, 5×10^-4M shifted the dose-response curve of NE to the right, whereas GX, 5×10^-4M, shifted the curve to the left. The maximum tension developed by K^+ was attenuated by lidocaine, 5×10^-4M, and GX, 2×10^-3M. It may be condcluded that lidocaine attenuates the response to stimulation of sympathetic nerves innervating the arterial wall by interfering with the release of NE. In contrast, GX potentiates the response, possibly by increaseing the release of NE.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1980-12
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部