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Surgical Treatment of Acute Arterial Insufficiency with Special Reference to Arteriosclerotic Obliterans

The bulletin of the Yamaguchi Medical School Volume 27 Issue 1-2 Page 47-54
published_at 1980-06
A020027000106.pdf
[fulltext] 1.26 MB
Title
Surgical Treatment of Acute Arterial Insufficiency with Special Reference to Arteriosclerotic Obliterans
Creators Esato Kensuke
Creators Nakahara Yasuo
Creators Kurata Satoru
Creators Kobayashi Osamu
Creators Shintani Kiyoshi
Creators Morita Nobuyoshi
Creators Mohri Hitoshi
Source Identifiers
Creator Keywords
embolism thrombosis acute arterial insufficiency arteriosclerois obliterans arteriovenous fistula
Lectin was extracted from the seeds of Abrus precatorius L. by affinity chromatography and ion exchange column chromatography and the purified lectins (AL-II_1 and AL-III_2 fractions) which had high hemagglutinating activity were obtained. The hemagglutinating avtivity of the AL-III_2 fraction was higher than that of the AL-II_1 fraction. On the other hand, the toxicity of the AL-III_2 fraction was comparatively lower than that of the AL-II_1 fraction. These abrus lectins induced ^3H-TdR incorporation, an increase in Feulgen-DNA content and blastoid transformation of human blood lymphocytes in vitro. The maximal degrees of blastoid trasformation were observed to be 4.5% in the AL-II_1 fraction and 6.4% in the AL-III_2 fraction. The blastoid cells induced by the abrus lectin resembled those of PHA culture in both size and staining characteristics. These results indicate that the abrus lectin has blastogenic property.
Subjects
医学 ( Other)
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University Graduate School of Medicine
Date Issued 1980-06
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 医学部