Comparative Effects of Angiotensin II Type 1 Receptor Blockade with Angiotensin-Converting -Enzyme Inhibitor on Aortic Smooth Muscle Cell Phenotype in Spontaneously Hypertensive Rats
The bulletin of the Yamaguchi Medical School Volume 43 Issue 3-4
Page 117-125
published_at 1996-12
Title
Comparative Effects of Angiotensin II Type 1 Receptor Blockade with Angiotensin-Converting -Enzyme Inhibitor on Aortic Smooth Muscle Cell Phenotype in Spontaneously Hypertensive Rats
Creators
Fujii Akihisa
Source Identifiers
Creator Keywords
Angiotensin II type 1 receptor blockade
Smooth muscle celｌ
Myosin heavy chain isoform
Fibrosis
Hypertension
To clarify the effects of renin-angiotensin system inhibition on aortic smooth muscle cell phennotype and fibrosis in spontaneously hypertensive rats (SHR), we treated 14-week -old SHR with a selective angiotensin II type 1 (AT1) receptor blockade, FK-739 (30mg/kg day) or sngiotensin-converting-enzyme (ACE) inhibitor, enalapril (10mg/kg/day) for 6 weeks. Both FK-739 and enalapril caused a significant decrease in blood pressere (p < 0.001) with no difference between the treated groups. Immunoblot showed no significant decrease in the expression of smooth muscle cell myosin heavy chain and nonmuscle myosin heavy chain (NMHC)-A in SHR aorta. In contrast, both FK- 739 and enalapril resulted in s significant decrease in the expression of NMHC-B compared with vehicle (vehicle vs FK-739 treated group
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University Graduate School of Medicine
Date Issued
1996-12
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
医学部