Iida Yasunori
Affiliate Master
Yamaguchi University
Immunoglobulin-resistant kawasaki disease associated with human parvovirus B19 infection
The bulletin of the Yamaguchi Medical School Volume 65 Issue 1-2
Page 21-25
published_at 2018
Title
Immunoglobulin-resistant kawasaki disease associated with human parvovirus B19 infection
Creators
Korenaga Yuno
Creators
Okada Seigo
Creators
Hirano Reiji
Creators
Ohga Shouichi
Source Identifiers
Creator Keywords
infliximab
Kawasaki disease
parvovirus B19
virus reactivation
A 23-month-old female presented with 6 full symptoms of Kawasaki disease (KD) and thrombocytopenic purpura of the lower extremities. Repeated intravenous immunoglobulin normalized the platelet counts, but not improved the activity of intractable KD. Primary infection of human parvovirus B19 (B19V) was determined at the diagnosis of KD based on the hypocomplementemia and the positive tests for anti-B19V IgM antibody. Infliximab therapy led to the complete resolution with no atypical or persistent infection of B19V, or coronary artery lesions. This is the first report of intravenous immunoglobulin-resistant KD associated with the primary infection of B19V. Successful treatment of the B19V-associated KD case suggested a clinical utility of the standard rescue infliximab for the treatment of intravenous immunoglobulin-resistant KD, possibly with concurrent infection. Abbreviations: B19V: human parvovirus B19, IVIG: ntravenous immunoglobulin, KD: Kawasaki disease
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University School of Medicine
Date Issued
2018
File Version
Version of Record
Access Rights
open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools
大学院医学系研究科(医学)