Matsumoto Hiroaki
Affiliate Master
Yamaguchi University
An invited review following the Soujinkai Fujiu Memorial Award : elucidation of drug resistance mechanisms in prostate cancer: overcome them by investigating bench to bedside
The bulletin of the Yamaguchi Medical School Volume 69 Issue 1-2
Page 1-9
published_at 2022-06
Title
An invited review following the Soujinkai Fujiu Memorial Award : elucidation of drug resistance mechanisms in prostate cancer: overcome them by investigating bench to bedside
Abstract
Androgen receptor (AR)-signaling plays an important role in promoting tumor cell survival and the development of castration-resistant prostate cancer (CRPC). Androgen deprivation therapy is the basic therapeutic strategy for AR signaling blockade, but that effects wonʼt last long and most of metastatic prostate cancer show castration resistance. Recently, new agents, AR Axis Targeted agents (ARAT), have been developed. We have been developing our bench-to-bedside translational research to elucidate the mechanisms of drug resistance in prostate cancer. This review describes our investigational results and recent advances in CRPC with ARAT treatment strategy.
Source Identifiers
[PISSN] 0513-1812
[EISSN] 2436-696X
Creator Keywords
castration-resistant prostate cancer
androgen receptor
clusterin
castrationsensitive prostate cancer
AR axis targeted agent
Languages
eng
Resource Type
departmental bulletin paper
Publishers
Yamaguchi University School of Medicine
Date Issued
2022-06
File Version
Version of Record
Access Rights
open access
Schools
大学院医学系研究科（医学）