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Okamura Takayuki

Affiliate Master Yamaguchi University

Relationship between the myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy

The bulletin of the Yamaguchi Medical School Volume 63 Issue 1-2 Page 5-16
published_at 2016
A050063000102.pdf
[fulltext] 661 KB
Title
Relationship between the myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy
Abstract
We investigated the relationship between myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy (TC) compared with acute anteroseptal myocardial infarction (AMI). Methods: In 10 TC patients and 10 AMI patients, electrocardiogram, echocardiography, cardiac catheterization were conducted, and plasma catecholamines and urinary (U) 8-hydroxy-2’-deoxyguanosine (8-OHdG) as a marker of oxidative DNA damage were taken for one week from onset. Results: On admission, the coronary sinus (CS) had significantly higher norepinephrine (NE) and 8-OHdG levels than the aortic root (Ao) and peripheral blood vessels. Circulating catecholamines in TC patients tended to be higher than those in AMI patients
Creators Oda Seiko
Creators Kobayashi Shigeki
Creators Nanno Takuma
Creators Ishiguchi Hironori
Creators Myoren Takeki
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Murakami Wakako
Creators Mochizuki Mamoru
Creators Oda Tetsuro
Creators Okuda Shinichi
Creators Yamada Jutaro
Creators Okamura Takayuki
Creators Matsuzaki Masanori
Affiliate Master Yamaguchi University
[kakenhi]15501 grid.268397.1
Creators Yano Masafumi
Source Identifiers [PISSN] 0513-1812 [NCID] AA00594272
Creator Keywords
takotsubo cardiomyopathy oxidative stress catecholamine
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2016
File Version Version of Record
Access Rights open access
Schools 医学部附属病院 大学院医学系研究科(医学)