Systemic inflammation and delirium in the periextubation period of mechanical ventilation : an observational prospective study of intensive care unit patients

Creators Ogino Yasuaki

Creators Kaneda Kotaro

Creators Nakahara Takashi

Creators Todani Masaki

Creators Miyauchi Takashi

Creators Fujita Motoki

Creators Kawamura Yoshikatsu

Creators Oda Yasutaka

Creators Tsuruta Ryosuke

Background: Delirium is a common problem in intensive care units (ICUs) and is associated with poor outcomes. The association between inflammation and delirium in the peri-extubation period of mechanical ventilation (MV) is poorly understood. Methods: We conducted a prospective, observational study of adult patients on MV for >48 hours in an ICU. At extubation (0 h) and 24 h later, the Confusion Assessment Method for the ICU (CAM-ICU) and the following serum biomarkers were assessed:C-reactive protein (CRP), procalcitonin, white blood cell (WBC) count, interleukin (IL)-6 and -8. Patients were classified into delirious (D

[ISSN]0513-1812

[NCID]AA00594272