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Hasegawa Shunji

Affiliate Master Yamaguchi University

Immunoglobulin-resistant kawasaki disease associated with human parvovirus B19 infection

The bulletin of the Yamaguchi Medical School Volume 65 Issue 1-2 Page 21-25
published_at 2018
A050065000103.pdf
[fulltext] 901 KB
Title
Immunoglobulin-resistant kawasaki disease associated with human parvovirus B19 infection
Creators Iida Yasunori
Creators Hasegawa Shunji
Creators Korenaga Yuno
Creators Okada Seigo
Creators Suzuki Yasuo
Creators Hirano Reiji
Creators Ohga Shouichi
Source Identifiers
Creator Keywords
infliximab Kawasaki disease parvovirus B19 virus reactivation
A 23-month-old female presented with 6 full symptoms of Kawasaki disease (KD) and thrombocytopenic purpura of the lower extremities. Repeated intravenous immunoglobulin normalized the platelet counts, but not improved the activity of intractable KD. Primary infection of human parvovirus B19 (B19V) was determined at the diagnosis of KD based on the hypocomplementemia and the positive tests for anti-B19V IgM antibody. Infliximab therapy led to the complete resolution with no atypical or persistent infection of B19V, or coronary artery lesions. This is the first report of intravenous immunoglobulin-resistant KD associated with the primary infection of B19V. Successful treatment of the B19V-associated KD case suggested a clinical utility of the standard rescue infliximab for the treatment of intravenous immunoglobulin-resistant KD, possibly with concurrent infection. Abbreviations: B19V: human parvovirus B19, IVIG: ntravenous immunoglobulin, KD: Kawasaki disease
Languages eng
Resource Type departmental bulletin paper
Publishers Yamaguchi University School of Medicine
Date Issued 2018
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1812
[NCID]AA00594272
Schools 大学院医学系研究科(医学)