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Muto Masahiko

Affiliate Master Yamaguchi University

MAID (mesna, adriamycin, ifosfamide, dacarbazine) combination chemotherapy in a patient with angiosarcoma of the skin

山口医学 Volume 64 Issue 3 Page 199-203
published_at 2015-08-01
B030064000305.pdf
[fulltext] 915 KB
Title
MAID療法を試みた頭部血管肉腫の1例
MAID (mesna, adriamycin, ifosfamide, dacarbazine) combination chemotherapy in a patient with angiosarcoma of the skin
Creators Kurata Yusuke
Creators Wakamatu Kenya
Creators Nakamura Yoshitaka
Creators Ichimiya Makoto
Creators Muto Masahiko
Source Identifiers [PISSN] 0513-1731 [NCID] AN00243156
Creator Keywords
血管肉腫 MAID療法
67歳,男性.頭頂部から左上眼瞼および右鼻翼にかけて広範囲に存在する紅斑と結節,潰瘍を主訴に当科紹介受診となった.病理組織学的所見において異型性のある腫瘍細胞が血管を模倣した管腔構造を呈しており,免疫染色においてCD31が陽性であったため,血管肉腫と診断した.明らかな遠隔転移は存在しなかったが,腫瘍が多発しており手術による完全切除が不可能と判断し,MAID(Mesna,Adriamycin,Ifosfamide,Dacarbazine)療法を行った.grade3の好中球減少とそれに伴う発熱を認めたが5コース終了時には腫瘍は著明に縮小しPR(partial response)が得られた.頭部血管肉腫は高齢者に好発するのが,自験例のように60歳代でpeformance status(以下PS)が0でありMAID療法を行うことができた稀な症例を経験したので,若干の文献的考察を加えここに報告した.
We report a case of angiosarcoma treated with combination chemotherapy (MAID:mesna, adriamycin, ifosfamide, dacarbazine). A 67-year-old man presented with an ulcerated, dark-red nodule and erythematous plaques on the scalp and upper left face. A skin biopsy of the lesion confirmed angiosarcoma. He was treated with MAID combination chemotherapy every 3 weeks due to unresectable tumor. After completing the fifth cycle, the lesion was decreased in size. MAID combination chemotherapy may offer a promising treatment option for angiosarcoma. Further investigations are necessary to confirm the efficacy of MAID combination chemotherapy for angiosarcoma.
Subjects
医学 ( Other)
Languages jpn
Resource Type journal article
Publishers 山口大学医学会
Date Issued 2015-08-01
File Version Version of Record
Access Rights open access
Relations
[ISSN]0513-1731
[NCID]AN00243156
Schools 大学院医学系研究科(医学)