Simvastatin reduces secretion of monocyte chemoattractant proteins and matrix metalloproteinase-9 in human abdominal aortic aneurysms

Creators Kudo Junichi

Creators Yoshimura Koichi

Creators Hamano Kimikazu

Recent studies have suggested that HMG-CoA reductase inhibitors (statins) attenuate the growth of human abdomical aortic aneurysm (AAA), which is characterized by chronic inflammation and degradation of the extracellular matrix by metalloproteinases (MMPs). While the effects of statins on inflammatory proteins have been reported, the molecular mechanism for the effect of statins on human AAA is largely unknown. Thus, the aim of this study was to elucidate the direct effect of statin on proinflammatory mediators in human AAA walls. Among 79 molecules analyzed by cytokine array, monocyte chemoattractant protein (MCP)-1 and MCP-3 were identified as markedly increased chemokines in human AAA…

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